Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct;96(5):1059-75.
doi: 10.1016/j.suc.2016.05.011.

Management of Gastrointestinal Stromal Tumors

Margaret von Mehren  1
Affiliations
Review

Management of Gastrointestinal Stromal Tumors

Margaret von Mehren. Surg Clin North Am. 2016 Oct.

Abstract

Gastrointestinal stromal tumors had the reputation for poor outcomes because of their lack of response to nonsurgical interventions. The discovery of gain-of-function mutations involving receptor tyrosine kinase growth factor receptors altered the biological understanding and management. Beginning in 2000, management of these tumors has changed dramatically because of the availability of tyrosine kinase inhibitors. The role of surgery continues to be refined. This article reviews how surgery and systemic therapy are being used, incorporating definitions of risk. Decisions on how to treat a patient is based on the risk of progression, pathologic characteristics, and tumor location.

Keywords: Adjuvant therapy; GIST; KIT; Metastasectomy; Neoadjuvant therapy; PDGFRA; SDH-deficient GIST; Tyrosine kinase inhibitors.

PubMed Disclaimer

LinkOut - more resources