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Comment
. 2016 Sep 6;113(36):E5257-8.
doi: 10.1073/pnas.1610228113. Epub 2016 Aug 19.

Tandem duplications contribute to not one but two distinct phenotypes

Johnathan Watkins  1 , Andrew Tutt  2 , Anita Grigoriadis  3
Affiliations
Comment

Tandem duplications contribute to not one but two distinct phenotypes

Johnathan Watkins et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Tandem duplication phenotypes in 940 TCGA breast cancers. (A and B) TDP status was determined using genomic segments between 1 Kbp and 2 Mbp (A), or 2 Mbp and 10 Mbp (B), followed by Gaussian mixture modeling of the ratio of TDs to non-TD segments (total number of segments minus double the number of TD segments as per ref. 2). Odds ratio and P value represent Fisher’s exact test of BRCA1 mutation enrichment in the TDP subset of tumors. BRCA1 loss was defined as germ-line or somatic point mutation or deletion. TDP tumors are colored in red and non-TDP tumors in gray. All samples are denoted by an “x,” with the exception of tumors with BRCA1 loss, which are denoted by a square. (C) Bar plots illustrate the overlaps between the different TDP calling methods.
See this image and copyright information in PMC

Comment in

Comment on

  • The tandem duplicator phenotype as a distinct genomic configuration in cancer.
    Menghi F, Inaki K, Woo X, Kumar PA, Grzeda KR, Malhotra A, Yadav V, Kim H, Marquez EJ, Ucar D, Shreckengast PT, Wagner JP, MacIntyre G, Murthy Karuturi KR, Scully R, Keck J, Chuang JH, Liu ET. Menghi F, et al. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2373-82. doi: 10.1073/pnas.1520010113. Epub 2016 Apr 7. Proc Natl Acad Sci U S A. 2016. PMID: 27071093 Free PMC article.

References

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