BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis

Robert S McNeill¹, David M Irvin², C Ryan Miller³

Affiliations

¹ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
² Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
³ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: rmiller@med.unc.edu.

PMID: 27543966
PMCID: PMC5222976
DOI: 10.1016/j.ajpath.2016.07.005

Comment

BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis

Robert S McNeill et al. Am J Pathol. 2016 Oct.

. 2016 Oct;186(10):2551-4.

doi: 10.1016/j.ajpath.2016.07.005. Epub 2016 Aug 18.

Authors

Robert S McNeill¹, David M Irvin², C Ryan Miller³

Affiliations

¹ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
² Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
³ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: rmiller@med.unc.edu.

PMID: 27543966
PMCID: PMC5222976
DOI: 10.1016/j.ajpath.2016.07.005

Abstract

This commentary highlights the article by Wang et al that describes a preclinical model for targeting BRAF-mutant gliomas.

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Comment on

Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.
Wang Q, Satomi K, Oh JE, Hutter B, Brors B, Diessl N, Liu HK, Wolf S, Wiestler O, Kleihues P, Koelsch B, Kindler-Röhrborn A, Ohgaki H. Wang Q, et al. Am J Pathol. 2016 Oct;186(10):2569-76. doi: 10.1016/j.ajpath.2016.05.024. Am J Pathol. 2016. PMID: 27658714

References

1. Wang Q., Satomi K., Oh J.E., Hutter B., Brors B., Nicolle D., Liu H., Wolf S., Wiestler O., Kleihues P., Koelsch B., Kindler-Röhrborn A., Ohgaki H. Braf mutations initiate the development of rat gliomas induced by postnatal exposure to n-ethyl-n-nitrosourea. Am J Pathol. 2016;186:2569–2576. - PubMed
1. Mendelsohn J. Personalizing oncology: perspectives and prospects. J Clin Oncol. 2013;31:1904–1911. - PubMed
1. Louis D.N., Perry A., Reifenberger G., von Deimling A., Figarella-Branger D., Cavenee W.K., Ohgaki H., Wiestler O.D., Kleihues P., Ellison D.W. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131:803–820. - PubMed
1. Cancer Genome Atlas Research Network Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med. 2015;372:2481–2498. - PMC - PubMed
1. Paugh B.S., Qu C., Jones C., Liu Z., Adamowicz-Brice M., Zhang J., Bax D.A., Coyle B., Barrow J., Hargrave D., Lowe J., Gajjar A., Zhao W., Broniscer A., Ellison D.W., Grundy R.G., Baker S.J. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol. 2010;28:3061–3068. - PMC - PubMed

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BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis

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BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis

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