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. 2016 Aug 7;22(29):6716-25.
doi: 10.3748/wjg.v22.i29.6716.

Hepatitis C virus G1b infection decreases the number of small low-density lipoprotein particles

Chika Kinoshita  1 , Tomohisa Nagano  1 , Nobuyoshi Seki  1 , Yoichi Tomita  1 , Tomonori Sugita  1 , Yuta Aida  1 , Munenori Itagaki  1 , Kenichi Satoh  1 , Satoshi Sutoh  1 , Hiroshi Abe  1 , Akihito Tsubota  1 , Yoshio Aizawa  1
Affiliations

Hepatitis C virus G1b infection decreases the number of small low-density lipoprotein particles

Chika Kinoshita et al. World J Gastroenterol. .

Abstract

Aim: To investigate how hepatitis C virus (HCV) G1b infection influences the particle number of lipoproteins.

Methods: The numbers of lipoprotein particles in fasting sera from 173 Japanese subjects, 82 with active HCV G1b infection (active HCV group) and 91 with cleared HCV infection (SVR group), were examined. Serum lipoprotein was fractionated by high-performance liquid chromatography into twenty fractions. The cholesterol and triglyceride concentrations in each fraction were measured using LipoSEARCH. The number of lipoprotein particles in each fraction was calculated using a newly developed algorithm, and the relationship between chronic HCV G1b infection and the lipoprotein particle number was determined by multiple linear regression analysis.

Results: The median number of low-density lipoprotein (LDL) particles was significantly lower in the active HCV group [1182 nmol/L, interquartile range (IQR): 444 nmol/L] than in the SVR group (1363 nmol/L, IQR: 472 nmol/L, P < 0.001), as was that of high-density lipoprotein (HDL) particles (14168 nmol/L vs 15054 nmol/L, IQR: 4114 nmol/L vs 3385 nmol/L, P = 0.042). The number of very low-density lipoprotein (VLDL) particles was similar between the two groups. Among the four LDL sub-fractions, the number of large LDL particles was similar between the two groups. However, the numbers of medium (median: 533.0 nmol/L, IQR: 214.7 nmol/L vs median: 633.5 nmol/L, IQR: 229.6 nmol/L, P < 0.001), small (median: 190.9 nmol/L, IQR: 152.4 nmol/L vs median: 263.2 nmol/L, IQR: 159.9 nmol/L; P < 0.001), and very small LDL particles (median: 103.5 nmol/L, IQR: 66.8 nmol/L vs median: 139.3 nmol/L, IQR: 67.3 nmol/L, P < 0.001) were significantly lower in the active HCV group than in the SVR group, respectively. Multiple linear regression analysis indicated an association between HCV G1b infection and the decreased numbers of medium, small, and very small LDL particles. However, active HCV infection did not affect the number of large LDL particles or any sub-fractions of VLDL and HDL particles.

Conclusion: HCV G1b infection decreases the numbers of medium, small, and very small LDL particles.

Keywords: Cholesterol; Chronic hepatitis C; Lipoprotein particles; Low-density lipoproteins; Regression analysis; Triglycerides; Very low-density lipoproteins.

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Figures

Figure 1
Figure 1
Comparison of the particle numbers of the three major lipoprotein classes for the active hepatitis C virus and sustained virological response groups. HCV: Hepatitis C virus; SVR: Sustained virological response.
Figure 2
Figure 2
Comparison of the particle numbers of the four low-density lipoprotein subclasses for the active hepatitis C virus and sustained virological response groups. HCV: Hepatitis C virus; SVR: Sustained virological response; LDL: Low-density lipoprotein.
Figure 3
Figure 3
Comparison of the particle numbers of the three very low-density lipoprotein subclasses for the active hepatitis C virus and sustained virological response groups. HCV: Hepatitis C virus; SVR: Sustained virological response; VLDL: Very low-density lipoprotein.
Figure 4
Figure 4
Comparison of the particle numbers of the three high-density lipoprotein subclasses for the active hepatitis C virus and Sustained virological response groups. HCV: Hepatitis C virus; SVR: Sustained virological response.
See this image and copyright information in PMC

References

    1. Dai CY, Chuang WL, Ho CK, Hsieh MY, Huang JF, Lee LP, Hou NJ, Lin ZY, Chen SC, Hsieh MY, et al. Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: a community-based study. J Hepatol. 2008;49:9–16. - PubMed
    1. Rubbia-Brandt L, Quadri R, Abid K, Giostra E, Malé PJ, Mentha G, Spahr L, Zarski JP, Borisch B, Hadengue A, et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol. 2000;33:106–115. - PubMed
    1. Negro F, Sanyal AJ. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int. 2009;29 Suppl 2:26–37. - PubMed
    1. Lerat H, Higgs M, Pawlotsky JM. Animal models in the study of hepatitis C virus-associated liver pathologies. Expert Rev Gastroenterol Hepatol. 2011;5:341–352. - PubMed
    1. Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T. PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin Invest. 2008;118:683–694. - PMC - PubMed