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Review
. 2016;89(3):327-34.
doi: 10.15386/cjmed-583. Epub 2016 Jul 28.

Hair loss and regeneration performed on animal models

Meda Sandra Orasan  1 , Iulia Ioana Roman  2 , Andrei Coneac  3 , Adriana Muresan  2 , Remus Ioan Orasan  2
Affiliations
Review

Hair loss and regeneration performed on animal models

Meda Sandra Orasan et al. Clujul Med. 2016.

Abstract

Research in the field of reversal hair loss remains a challenging subject. As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical approach in alopecia. In vitro studies have focused on cultures of a cell type - dermal papilla or organ culture of isolated cell follicles. In vivo research on this topic was performed on mice, rats, hamsters, rabbits, sheep and monkeys, taking into consideration the advantages and disadvantages of each animal model and the depilation options. Further studies are required not only to compare the efficiency of different therapies but more importantly to establish their long term safety.

Keywords: alopecia; animal models; hair regrowth; research in vivo.

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