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. 2016 Aug 8;5(1):1278.
doi: 10.1186/s40064-016-2949-z. eCollection 2016.

Health-related quality of life after deep vein thrombosis

Kristin Kornelia Utne  1 , Mazdak Tavoly  2 , Hilde Skuterud Wik  3 , Lars Petter Jelsness-Jørgensen  4 , René Holst  5 , Per Morten Sandset  6 , Waleed Ghanima  7
Affiliations

Health-related quality of life after deep vein thrombosis

Kristin Kornelia Utne et al. Springerplus. .

Abstract

Background: Health-related quality of life (HRQoL) is known to be impaired in patients who develop post-thrombotic syndrome (PTS) following deep vein thrombosis (DVT). However, there is limited knowledge of the long-term HRQoL after DVT compared to controls without DVT. The objectives of this study were to evaluate long-term HRQoL following DVT and to compare that with age and sex matched control group and to population norms as well as to investigate possible predictors for reduced HRQoL.

Methods: HRQoL was evaluated in 254 patients with confirmed DVT using the generic EQ-5D and the diseases specific VEINES-QOL/Sym questionnaire, whereas PTS was assessed by the Villalta scale. Patients were asked to give the EQ-5D questionnaire to two friends of same age- (±5 years) and sex (buddy controls).

Results: Patients scored significantly lower on all dimensions of EQ-5D compared to controls. EQ-5D index value was lower in patients compared with buddy controls; mean 0.79 (SD 0.17; IQR 0.72-1.00) versus 0.9 (SD 0.12; IQR 0.80-1.00), p < 0.001. EQ-5D index value was also significantly lower than age- and sex-adjusted population norms (p < 0.001). PTS and obesity (BMI >30/m(2)) were significantly associated with impaired HRQoL assessed by EQ-5D index value (odds ratio [OR] 11.0: 95 % confidence interval [CI] 4.6-29.7; and 2.3: 95 % CI 1.1-4.8, respectively) and VEINES-QOL (OR 28.2: 95 % CI 10.6-75.0; and OR 4.1: 95 % CI 1.7-9.7, respectively).

Conclusion: Long-term HRQoL was significantly impaired in DVT patients compared with buddy controls and population norms. PTS and obesity were independently associated with impaired HRQoL.

Keywords: Controls; Deep vein thrombosis; EQ-5D-3L; HRQoL; Population norms; VEINES-QOL/Sym.

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Figures

Fig. 1
Fig. 1
Flow-chart of patient sample
See this image and copyright information in PMC

References

    1. Ashrani AA, Heit JA. Incidence and cost burden of post-thrombotic syndrome. J Thromb Thrombolysis. 2009;28(4):465–476. doi: 10.1007/s11239-009-0309-3. - DOI - PMC - PubMed
    1. Baldwin MJ, Moore HM, Rudarakanchana N, Gohel M, Davies AH. Post-thrombotic syndrome: a clinical review. J Thromb Haemost. 2013;11(5):795–805. doi: 10.1111/jth.12180. - DOI - PubMed
    1. Brooks R. EuroQol: the current state of play. Health Policy. 1996;37(1):53–72. doi: 10.1016/0168-8510(96)00822-6. - DOI - PubMed
    1. Casais P, Meschengieser SS, Sanchez-Luceros A, Lazzari MA. Patients’ perceptions regarding oral anticoagulation therapy and its effect on quality of life. Curr Med Res Opin. 2005;21(7):1085–1090. doi: 10.1185/030079905X50624. - DOI - PubMed
    1. Catarinella F, Nieman F, de Wolf M, Wittens C. Short-term follow-up of Quality-of-Life in interventionally treated patients with post-thrombotic syndrome after deep venous occlusion. Phlebology. 2014;29(1 suppl):104–111. doi: 10.1177/0268355514529505. - DOI - PubMed