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. 2016 Aug 9:2:28.
doi: 10.1186/s40798-016-0055-y. eCollection 2015 Jun.

Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease

Patrick S Tucker  1 , Aaron T Scanlan  1 , Rebecca K Vella  2 , Vincent J Dalbo  1
Affiliations

Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease

Patrick S Tucker et al. Sports Med Open. .

Abstract

Background: Chronic kidney disease (CKD) is an irreversible disease that diminishes length and quality of life. Emerging evidence suggests CKD progression and genomic integrity are inversely and causally related. To reduce health complications related to CKD progression, chronic aerobic exercise is often recommended. To date, appraisals of differing modes of exercise, along with postulations regarding the mechanisms responsible for observed effects, are lacking. In order to examine the ability of aerobic exercise to encourage improvements in genomic integrity, we evaluated the effects of 8 weeks of high-intensity interval training (HIIT; 85 % VO2max), low intensity training (LIT; 45-50 % VO2max), and sedentary behaviour (SED), in an animal model of early-stage CKD.

Methods: To assess genomic integrity, we examined kidney-specific messenger RNA (mRNA) expression of genes related to genomic repair and stability: Fan1, Mre11a, and telomere length as measured by T/S ratio.

Results: Following HIIT, mRNA expression of Fan1 was significantly up-regulated, compared to SED (p = 0.026) and T/S ratio was significantly increased, compared to SED (p < 0.001) and LIT (p = 0.002).

Conclusions: Our results suggest that HIIT is superior to SED and LIT as HIIT beneficially influenced the expression of genes related to genomic integrity.

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Figures

Fig. 1
Fig. 1
The primary mechanisms responsible for the progression of CKD: interactions between free radicals and reactive oxygen species, renal DNA, and inflammation mediators
Fig. 2
Fig. 2
a–c mRNA related to genomic health—expression fold change
See this image and copyright information in PMC

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