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Review
. 2016 Sep;13 Suppl 3(Suppl 3):8-14.
doi: 10.1111/iwj.12662.

Wound bed preparation: TIME for an update

Rhiannon L Harries  1 , David C Bosanquet  2 , Keith G Harding  3
Affiliations
Review

Wound bed preparation: TIME for an update

Rhiannon L Harries et al. Int Wound J. 2016 Sep.

Abstract

While the overwhelming majority of wounds heal rapidly, a significant proportion fail to progress through the wound-healing process. These resultant chronic wounds cause considerable morbidity and are costly to treat. Wound bed preparation, summarised by the TIME (Tissue, Inflammation/infection, Moisture imbalance, Epithelial edge advancement) concept, is a systematic approach for assessing chronic wounds. Each of these components needs to be addressed and optimised to improve the chances of successful wound closure. We present an up-to-date literature review of the most important recent aspects of wound bed preparation. While there are many novel therapies that are available to the treating clinician, often, there are limited data on which to assess their clinical value, and a lack of appreciation for adequate wound bed preparation needed before expensive therapy is used to heal a wound.

Keywords: Chronic wounds; Wound bed preparation; Wound healing.

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Figures

Figure 1
Figure 1
The TIME concept.
Figure 2
Figure 2
Wound infection spectrum.
See this image and copyright information in PMC

References

    1. Schultz GS, Sibbald RG, Falanga V, Ayello EA, Dowsett C, Harding K, Romanelli M, Stacey MC, Teot L, Vanscheidt W. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003;11:S1–28. - PubMed
    1. Schultz GS, Barillo DJ, Mozingo DW, Chin GA. Wound bed preparation and a brief history of TIME. Int Wound J 2004;1:19–32. - PMC - PubMed
    1. Bosanquet DC, Harding KG. Wound duration and healing rates: cause or effect? Wound Repair Regen 2014;22:143–50. - PubMed
    1. European Wound Management Association (EWMA) . Position document: wound bed preparation in practice. XXX: European Wound Management Association, 2004.
    1. Gethin G, Cowman S, Kolbach DN. Debridement for venous leg ulcers. Cochrane Database Syst Rev 2015;9:CD008599. - PMC - PubMed

MeSH terms