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. 2016 Aug 17;21(8):1075.
doi: 10.3390/molecules21081075.

Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

Bing-You Yang  1 , Jing Zhang  2 , Yan Liu  3 , Hai-Xue Kuang  4
Affiliations

Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

Bing-You Yang et al. Molecules. .

Abstract

Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively.

Keywords: Asparagaceae; MTT; cytotoxicity; furostanol saponin; spirostanol saponin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–8 from Anemarrhena asphodeloides.
Figure 2
Figure 2
Key HMBC and 1H-1H COSY correlations (a) of compound 1; Key NOESY correlations (b) of compound 1.
Figure 3
Figure 3
(a) Inhibition of HepG2 cell proliferation by the tested compounds; (b) Inhibition of SGC7901 cell proliferation by the tested compounds.
See this image and copyright information in PMC

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