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Comparative Study
. 2017 Mar;11(2):426-434.
doi: 10.1177/1557988316664074. Epub 2016 Aug 22.

Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects

Somaye Yosaee  1   2 , Mahmoud Khodadost  3 , Alireza Esteghamati  4 , John R Speakman  5 , Farzad Shidfar  1 , Mahdiyeh Nasab Nazari  4 , Vida Bitarafan  4 , Kurosh Djafarian  4
Affiliations
Comparative Study

Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects

Somaye Yosaee et al. Am J Mens Health. 2017 Mar.

Abstract

Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, is a challenging public health issue. The aim of current study was to test the hypothesis that concentrations of plasma adropin and leptin differ between patients with MetS and comparable age- and sex-matched control groups. This case-control study involved 153 subjects (51 per group). The study group included obese subjects with MetS and the two control groups included weight-matched subjects without MetS ("healthy": obese) and normal weight subjects without MetS. Body composition parameters were measured using bioelectrical impedance analysis. Plasma levels of adropin, leptin, and their ratio were measured. Leptin was significantly different between obese patients with/without MetS groups and normal weight subjects. Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p = .002). Compared with healthy obese and normal weight subjects, MetS subjects had lower levels of plasma adropin ( p < .001) and a lower plasma adropin to leptin ratio ( p < .001), which remained significant when adjusted for body fat mass by analysis of covariance ( p < .001). This study demonstrates low levels of adropin are correlated with MetS and hence identify it as a potentially protective agent against MetS development. Variation in adropin levels may partly explain the "healthy obese" phenomenon.

Keywords: adropin; body composition; leptin; metabolic syndrome; obesity.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The ROC curve for determining the adropin cutoff point in diagnosing of MetS. Note. AUC = area under the curve; CI = confidence interval; SE = standard error; ROC = receiver operator characteristic; MetS = metabolic syndrome.
Figure 2.
Figure 2.
Trend of adropin and leptin according to number of MetS components. Note. MetS = metabolic syndrome.
Figure 3.
Figure 3.
Trend of adropin and leptin according to study groups. Note. MetS = metabolic syndrome.
See this image and copyright information in PMC

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