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. 2016 Jul 22:12:300-5.
doi: 10.1016/j.nicl.2016.07.009. eCollection 2016.

Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder

Yuko Yoshimura  1 , Mitsuru Kikuchi  1 , Hirotoshi Hiraishi  1 , Chiaki Hasegawa  1 , Tetsuya Takahashi  1 , Gerard B Remijn  2 , Manabu Oi  1 , Toshio Munesue  1 , Haruhiro Higashida  1 , Yoshio Minabe  1
Affiliations

Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder

Yuko Yoshimura et al. Neuroimage Clin. .

Abstract

The auditory-evoked P1m, recorded by magnetoencephalography, reflects a central auditory processing ability in human children. One recent study revealed that asynchrony of P1m between the right and left hemispheres reflected a central auditory processing disorder (i.e., attention deficit hyperactivity disorder, ADHD) in children. However, to date, the relationship between auditory P1m right-left hemispheric synchronization and the comorbidity of hyperactivity in children with autism spectrum disorder (ASD) is unknown. In this study, based on a previous report of an asynchrony of P1m in children with ADHD, to clarify whether the P1m right-left hemispheric synchronization is related to the symptom of hyperactivity in children with ASD, we investigated the relationship between voice-evoked P1m right-left hemispheric synchronization and hyperactivity in children with ASD. In addition to synchronization, we investigated the right-left hemispheric lateralization. Our findings failed to demonstrate significant differences in these values between ASD children with and without the symptom of hyperactivity, which was evaluated using the Autism Diagnostic Observational Schedule, Generic (ADOS-G) subscale. However, there was a significant correlation between the degrees of hemispheric synchronization and the ability to keep still during 12-minute MEG recording periods. Our results also suggested that asynchrony in the bilateral brain auditory processing system is associated with ADHD-like symptoms in children with ASD.

Keywords: ADHD, attention deficit hyperactivity disorder; AEF, auditory-evoked field; ASD, autism spectrum disorder; Autism spectrum disorder (ASD); ECD, equivalent current dipole; Hyperactivity; ISI, inter-stimulus interval; MEG, magnetoencephalography; Magnetoencephalography (MEG); P1m; TD, typically developing; Young children.

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Figures

Fig. 1
Fig. 1
Waveform of the /ne/ speech stimulus. The total duration was 342 ms, with 65 ms for the consonant /n/ and 277 ms for the post-consonantal vowel sound /e/. The onset time for MEG averaging was set at the start of the vowel.
Fig. 2
Fig. 2
Waveform of P1m (a) and dipole source in auditory cortex (b). The red sphere indicates the dipole source, and the red bar indicates the direction of the current source. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
Fig. 3
Fig. 3
Scatter plot showing strong positive linear correlation between the synchronization index in P1m and the index of stillness during MEG recording in 31 children with ASD. Children with ASD who were able to keep still during 12 min of MEG recording showed higher interhemispheric synchronization in the P1m peak latency.
See this image and copyright information in PMC

References

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