Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

doi:10.1016/j.schres.2016.08.011

. 2016 Oct;176(2-3):144-150.

doi: 10.1016/j.schres.2016.08.011. Epub 2016 Aug 21.

Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

Jung Sun Lee¹, Chang-Yoon Kim², Yeon Ho Joo², Dominick Newell³, Sylvain Bouix³, Martha E Shenton⁴, Marek Kubicki⁵

Affiliations

¹ Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
³ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: kubicki@bwh.harvard.edu.

PMID: 27554199
PMCID: PMC5392041
DOI: 10.1016/j.schres.2016.08.011

Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

Jung Sun Lee et al. Schizophr Res. 2016 Oct.

. 2016 Oct;176(2-3):144-150.

doi: 10.1016/j.schres.2016.08.011. Epub 2016 Aug 21.

Authors

Jung Sun Lee¹, Chang-Yoon Kim², Yeon Ho Joo², Dominick Newell³, Sylvain Bouix³, Martha E Shenton⁴, Marek Kubicki⁵

Affiliations

¹ Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
³ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: kubicki@bwh.harvard.edu.

PMID: 27554199
PMCID: PMC5392041
DOI: 10.1016/j.schres.2016.08.011

Erratum in

Corrigendum to "Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition" [Schizophr. Res. 176 (2-3) (Oct 2016) 144-150].
Lee JS, Kim CY, Joo YH, Newell D, Bouix S, Shenton ME, Kubicki M. Lee JS, et al. Schizophr Res. 2017 Mar;181:137. doi: 10.1016/j.schres.2016.11.001. Epub 2016 Nov 25. Schizophr Res. 2017. PMID: 27890401 No abstract available.

Abstract

Introduction: Diffusion weighted MRI (dMRI) is a method sensitive to pathological changes affecting tissue microstructure. Most dMRI studies in schizophrenia, however, have focused solely on white matter. There is a possibility, however, that subtle changes in diffusivity exist in gray matter (GM). Accordingly, we investigated diffusivity in GM in patients with recent onset schizophrenia.

Methods: We enrolled 45 patients and 21 age and sex-matched healthy controls. All subjects were evaluated using the short form of the Wechsler Adult Intelligence Scale, the Positive and Negative Syndrome Scale (PANSS), and the video based social cognition scale. DMRI and T1W images were acquired on a 3 Tesla magnet, and mean Fractional Anisotropy (FA), Trace (TR) and volume were calculated for each of the 68 cortical GM Regions of Interest parcellated using FreeSurfer.

Results: There was no significant difference of FA and GM volume between groups after Bonferroni correction. For the dMRI measures, however, patients evinced increased TR in the left bank of the superior temporal sulcus, the right inferior parietal, the right inferior temporal, and the right middle temporal gyri. In addition, higher TR in the right middle temporal gyrus and the right inferior temporal gyrus, respectively, was associated with decreased social function and higher PANSS score in patients with schizophrenia.

Conclusion: This study demonstrates high sensitivity of dMRI to subtle pathology in GM in recent onset schizophrenia, as well as an association between increased diffusivity in temporal GM regions and abnormalities in social cognition and exacerbation of psychiatric symptoms.

Keywords: Diffusivity; Gray matter; MRI; Schizophrenia.

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Conflict of interest statement

Conflict of interest

All authors declare that they have no conflict of financial interest.

Figures

**Fig. 1**
Correlation between trace and video based social cognition in right middle Temporal gyrus

**Fig. 2**
Correlation between PANSS total score and mean trace in right inferior temporal gyrus

See this image and copyright information in PMC

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References

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[1] Abdul-Rahman MF, Qiu A, Woon PS, Kuswanto C, Collinson SL, Sim K. Arcuate fasciculus abnormalities and their relationship with psychotic symptoms in schizophrenia. PLoS ONE. 2012;7:e29315. - PMC - PubMed

[2] Abdul-Rahman MF, Qiu A, Woon PS, Kuswanto C, Collinson SL, Sim K. Arcuate fasciculus abnormalities and their relationship with psychotic symptoms in schizophrenia. PLoS ONE. 2012;7:e29315. - PMC - PubMed

[3] Adolphs R. The neurobiology of social cognition. Curr Opin Neurobiol. 2001;11:231–239. - PubMed

[4] Adolphs R. The neurobiology of social cognition. Curr Opin Neurobiol. 2001;11:231–239. - PubMed

[5] Alexander AL, Hurley SA, Samsonov AA, Adluru N, Hosseinbor AP, Mossahebi P, Tromp DPM, Zakszewski E, Field AS. Characterization of Cerebral White Matter Properties Using Quantitative Magnetic Resonance Imaging Stains. Brain Connectivity. 2011;1:423–446. - PMC - PubMed

[6] Alexander AL, Hurley SA, Samsonov AA, Adluru N, Hosseinbor AP, Mossahebi P, Tromp DPM, Zakszewski E, Field AS. Characterization of Cerebral White Matter Properties Using Quantitative Magnetic Resonance Imaging Stains. Brain Connectivity. 2011;1:423–446. - PMC - PubMed

[7] Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316–329. - PMC - PubMed

[8] Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316–329. - PMC - PubMed

[9] Assaf Y, Pasternak O. Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review. J Mol Neurosci. 2007;34:51–61. - PubMed

[10] Assaf Y, Pasternak O. Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review. J Mol Neurosci. 2007;34:51–61. - PubMed

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Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

Affiliations

Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

Figures

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Cited by

References

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Erratum in

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