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Comment
. 2016 Sep;65(9):2470-2.
doi: 10.2337/dbi16-0025.

Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?

Leslie S Satin  1 , Joon Ha  2 , Arthur S Sherman  2
Affiliations
Comment

Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?

Leslie S Satin et al. Diabetes. 2016 Sep.
No abstract available

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Figures

Figure 1
Figure 1
A: Schematic of the experimental preparation. Islets transplanted to the anterior chamber of the eye can be evaluated through the lens for β-cell mass and calcium dynamics, while whole-body glucose and insulin are sampled from the circulation. B: Proposed hierarchy of β-cell adaptations to insulin resistance 1: Normal exercise of the glucose dose-response curve: glucose metabolism increases ATP/ADP ratio and closes K(ATP) channels. 2: Persistent hyperglycemia leads to reduced K(ATP) channel density, shifting the dose-response curve to the left (3). If 2 is insufficient, calcium efficacy is increased by enhanced trafficking of vesicles to the plasma membrane (PM) (3). If 2 and 3 are insufficient, β-cell replication (4) is stimulated. C: Simulations of β-cell response to reduced insulin sensitivity using the model of Ha et al. (10). β-Cell mass (blue) rises slowly, whereas the functional index (stimulated plasma insulin over β-cell mass [orange]) rises rapidly. At 17 weeks, returning mice to normal chow reverses augmented β-cell function, while β-cell mass approaches a plateau.
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