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. 2016 Jul 28:9:4687-94.
doi: 10.2147/OTT.S97699. eCollection 2016.

The impact of the extent of surgical resection on survival of gastric cancer patients

Kostadin Georgiev Angelov  1 , Mariela Borisova Vasileva  1 , Konstantin Savov Grozdev  1 , Svetoslav Yordanov Toshev  1 , Manol Bonev Sokolov  1 , Georgi Todorov Todorov  1
Affiliations

The impact of the extent of surgical resection on survival of gastric cancer patients

Kostadin Georgiev Angelov et al. Onco Targets Ther. .

Abstract

Objective: The aim of this study was to examine the significance of the extent of gastric resection on the postoperative and overall gastric cancer survival.

Background: Resection with clean margins (4 cm or more) is widely accepted as the standard-ized goal for radical treatment of gastric cancer according to current guidelines, while the type of resection (subtotal or total) is still a matter of debate.

Patients and methods: The study included 155 patients diagnosed and treated in the Department of Surgery, Aleksandrovska University Hospital between January 2005 and December 2014. In order to determine the significance of the resection volume, we excluded from the study 54 patients receiving palliative intervention or staging exploratory laparoscopy. The remaining 101 patients were divided into two groups based on the volume of the performed gastric resection (total and subtotal) and compared based on overall survival and perioperative mortality. We also investigated the 3-year survival in the two groups as well as the overall survival only in the subgroup of patients with D2 lymphadenectomy.

Results: We could not determine any statistically significant difference in overall survival and 3-year survival (P=0.990) based on the extent of surgical resection (P=0.824) or perioperative mortality. The statistical analysis on patients with D2 lymph node dissection only did not show significance for overall survival.

Conclusion: Our study shows no difference in safety and long-term survival rate of patients with gastric carcinoma based on the volume of stomach resection. Comparison with other studies also shows no difference in survival based on volume of the resection.

Keywords: gastric cancer; overall survival; perioperative mortality.

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Figures

Figure 1
Figure 1
Study design.
Figure 2
Figure 2
Patient groups based on the type of operation performed, n (%).
Figure 3
Figure 3
Overall survival rate of 101 patients based on the volume of gastric resection.
Figure 4
Figure 4
The comparison of postoperative mortality within 30 days after surgery according to average age of the patient.
Figure 5
Figure 5
Three-year survival rate function according to resection type.
Figure 6
Figure 6
Overall survival of patients with D2 lymph dissection according to the volume of gastric resection.
See this image and copyright information in PMC

References

    1. World Health Organization [homepage on the Internet] GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. WHO, International Agency for Research on Cancer; 2012. [Accessed May 4, 2016]. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
    1. sbaloncology.bg [homepage on the Internet] [Accessed May 4, 2016];Bulgarian National Cancer Registry, Cancer Incidence in Bulgaria 2011, TOM XXII. 2013 XXII Available from: http://www.sbaloncology.bg/en/ncr.html.
    1. Japanese Gastric Cancer Association Japanese gastric cancer treatment guidelines 2010 (ver. 3) Gastric Cancer. 2011;14(2):113–123. - PubMed
    1. Kuo CY, Chao Y, Li CP. Update on treatment of gastric cancer. J Chin Med Assoc. 2014;77(7):345–353. - PubMed
    1. National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Gastric Cancer. v.3.2015. [Accessed October 30, 2015]. Available from: http://www.nccn.org/PDF/gastric.pdf.