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Case Reports
. 2016 Nov;41(11):877-878.
doi: 10.1097/RLU.0000000000001335.

Aspecific Uptake of 68GA-PSMA in Paget Disease of the Bone

Sophie Bourgeois  1 , Pieterjan Gykiere, Lode Goethals, Hendrik Everaert, Frank W De Geeter
Affiliations
Case Reports

Aspecific Uptake of 68GA-PSMA in Paget Disease of the Bone

Sophie Bourgeois et al. Clin Nucl Med. 2016 Nov.

Abstract

Ga-PSMA plays an increasing role in prostate cancer management, but several instances of false positivity have now been recognized. We present a patient with metastatic prostatic carcinoma who also showed overexpression of PSMA in Paget disease of the humerus on Ga-PSMA PET. This probably relates to bone remodeling and increased vascularity. It is important to be aware of this aspecific uptake because its recognition may avoid overstaging and may alter the therapeutic choice.

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