T Cell responses: Defective mitochondria disrupt CD8(+) T cells

Comment

Olive Leavy. Nat Rev Immunol. 2016.

. 2016 Aug 25;16(9):534-5.

doi: 10.1038/nri.2016.98.

No abstract available

Comment on

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bengsch B, et al. Immunity. 2016 Aug 16;45(2):358-73. doi: 10.1016/j.immuni.2016.07.008. Epub 2016 Aug 2. Immunity. 2016. PMID: 27496729 Free PMC article.
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. Scharping NE, et al. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. Epub 2016 Aug 2. Immunity. 2016. PMID: 27496732 Free PMC article.