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Editorial
. 2016 Dec 16;15(24):3319-3320.
doi: 10.1080/15384101.2016.1222747. Epub 2016 Aug 25.

Disabled-2; an autophagic and apoptotic switch

Yong Jiang  1 , Alec N Woosley  1 , Philip H Howe  1   2
Affiliations
Editorial

Disabled-2; an autophagic and apoptotic switch

Yong Jiang et al. Cell Cycle. .
No abstract available

Keywords: Apoptosis; Cathepsin B; Disabled-2; TGFb; autophagy.

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Figures

Figure 1.
Figure 1.
Role of Disabled-2 (Dab2) in TGFβ-mediated autophagy. Chronic TGFβ treatment induces the expression of the protease cathepsin B (CTSB) leading the cleavage and degradation of wild-type Dab2 (WT Dab2). Loss of Dab2 allows Beclin-1/Vps34 interactions, initiation of the autophagosome formation and an increase in autophagy. CTSB attenuation or expression of a non-CTSB cleavage mutant form of Dab2 (Mut. Dab2) facilitates CK2-mediated Beclin-1 phosphorylation resulting in loss of Beclin-1/Vps34 association, autophagosome platform dissociation, and subsequent inhibition of autophagy. Dab2 prevents ERK-mediated Bim phosphorylation and degradation and stabilizes TGFβ-induced Bim expression to promote apoptosis.
See this image and copyright information in PMC

Comment on

  • Feature to: Jiang Y, et al. Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy. Nat Cell Biol 2016; 18(8):851-63; PMID: ; http://dx.doi.org/10.1038/ncb3388.

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