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. 2016 Dec;35(12):1578-1583.
doi: 10.1097/ICO.0000000000001002.

Characterizing Contact Lens-Related Corneal Infiltrates: A Pilot Study

Meredith E Jansen  1 , Ping Situ, Carolyn G Begley, Danielle Boree, Robin L Chalmers, Kathrine Osborn Lorenz, Tawnya Wilson
Affiliations

Characterizing Contact Lens-Related Corneal Infiltrates: A Pilot Study

Meredith E Jansen et al. Cornea. 2016 Dec.

Abstract

Purpose: To document the time course and resolution of contact lens-related corneal infiltrative events (CIEs) comparing slit-lamp images with anterior segment ocular coherence tomography (AS-OCT) images.

Methods: Six silicone hydrogel (SiHy) soft contact lens (SCL) wearers presenting with newly diagnosed symptomatic CIEs were monitored with slit-lamp images, detailed drawings, and AS-OCT until the resolution of the CIE. A final follow-up visit was completed 4 weeks after CIE resolution to determine whether scar formation was present. Positive controls were 2 SiHy SCL wearers with established (inactive) corneal scars, and negative controls were 2 SiHy SCL wearers with clear corneas. High- and low-contrast logMAR visual acuities were measured, and subjective symptom questionnaires were completed at all visits.

Results: Clinical signs, vision, and symptoms improved in tandem with the resolution of the CIEs as measured by imaging methods. Calibrated measures of infiltrate width from a slit-lamp biomicroscope appear to be similar to calibrated images from AS-OCT.

Conclusions: Although further studies are needed to develop standardized procedures, AS-OCT can be a useful tool to characterize the development, progression, and resolution of corneal infiltrates as an objective measure of resolution and scar formation.

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Conflict of interest statement

M. E. Jansen, D. Boree, K. Osborn Lorenz, and T. Wilson are employees of Johnson and Johnson Vision Care, Inc. P. Situ and C. G. Begley are employees of Indiana University School of Optometry. R. L. Chalmers is a private consultant.

Figures

FIGURE 1.
FIGURE 1.
The average (±SD) high-contrast logMAR acuity for all study visits. Add V1-V5 denotes additional visits for the infiltrate group only.
FIGURE 2.
FIGURE 2.
The average (±SD) low-contrast logMAR acuity for all study visits. Add V1-V5 denotes additional visits for the infiltrate group only.
FIGURE 3.
FIGURE 3.
The average (±SD) horizontal and vertical infiltrate/scar size (mm) for infiltrate subjects as measured by the clinician at some study visits.
FIGURE 4.
FIGURE 4.
The average (±SD) depth of infiltrates/scars measured by AS-OCT caliper software (μm) for infiltrate subjects at some study visits.
FIGURE 5.
FIGURE 5.
AS-OCT and slit-lamp biomicroscopy images from subject 8. Measurements are of infiltrate width with each method after calibration (AS-OCT images were missing from additional visit 2, but the slit-lamp measure of infiltrate width was 0.56 mm). Arrows and circles identify infiltrate location.
FIGURE 6.
FIGURE 6.
AS-OCT and slit-lamp biomicroscopy images from subject 9. Measurements are of infiltrate width with each method after calibration. Arrows and circles identify infiltrate location.
FIGURE 7.
FIGURE 7.
Enlarged AS-OCT images from subject 8 and subject 9 at visit 1 and additional visits showing changes in infiltrate edges over time that correspond with marked symptom improvement.
See this image and copyright information in PMC

References

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