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. 2016 Aug 25:22:2999-3008.
doi: 10.12659/msm.897104.

Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease

Jing-Fang Li  1 , Dian-Ying Peng  2 , Mei Ling  3 , Yong Yin  4
Affiliations

Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease

Jing-Fang Li et al. Med Sci Monit. .

Abstract

BACKGROUND This meta-analysis investigated the correlation of ABCA1 R219K and C-Reactive Protein Gene (CRP) +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). MATERIAL AND METHODS We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. RESULTS Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.

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Figures

Figure 1
Figure 1
The gene loci on ABCA1 R219K (rs2230806) and CRP +1059G/C (rs1800947).
Figure 2
Figure 2
Flow chart shows the study selection procedure. Eleven studies were included.
Figure 3
Figure 3
Forest plots for the differences of genotype and allele frequencies in the correlation of ABCA1 R219K and CRP +1059G/C polymorphisms with susceptibility to coronary heart disease.
Figure 4
Figure 4
Meta-regression analysis for the differences of genotype and allele frequencies in the correlation of ABCA1 R219K and CRP +1059G/C polymorphisms with susceptibility to coronary heart disease.
Figure 5
Figure 5
Sensitivity analysis of the summary odds ratio coefficients for the differences of genotype and allele frequencies in the correlation of ABCA1 R219K and CRP +1059G/C polymorphisms with susceptibility to coronary heart disease.
Figure 6
Figure 6
Publication biases for genotype and allele frequencies in the correlation of ABCA1 R219K and CRP +1059G/C polymorphisms with susceptibility to coronary heart disease.
See this image and copyright information in PMC

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