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Comment
. 2016 Aug 25;12(8):e1005740.
doi: 10.1371/journal.ppat.1005740. eCollection 2016 Aug.

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days

Mykola Pinkevych  1 , Stephen J Kent  2   3   4 , Martin Tolstrup  5 , Sharon R Lewin  3   4 , David A Cooper  1 , Ole S Søgaard  5 , Thomas A Rasmussen  3   5 , Anthony D Kelleher  1 , Deborah Cromer  1 , Miles P Davenport  1
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Comment

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days

Mykola Pinkevych et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Estimating HIV reactivation rate using different models.
The figure compares the fitting of the best-fit reactivation rate to each of the four cohorts using the original simple two-parameter model (panels A–D) as well as the more complex model proposed by Hill et al. that incorporates multiple reactivation events and a distribution in reactivation rates. The latter is fitted using a washout time of 0 days and either Hill et al.’s proposed slow viral growth rate (g = 0.4/day) (panels E–H) or a more realistic growth rate estimated from cohort 1 (g = 0.8/day) (panels I–L). In each case, the initial viral load (V 0) and the mean and standard deviation of the reactivation rate is fitted. The average time between reactivation events is indicated for each cohort. Only for cohort 3, with a low growth rate (panel g), is estimated reactivation rate more frequent than once every 2 days. *Note: although a distribution in reactivation rates was fitted, the best fit model had a standard deviation of zero.
Fig 2
Fig 2. Frequency of HIV reactivation from latency estimated using different models: The mean frequency of reactivation estimated using the original model (red circles, corresponding to panels A–D of Fig 1), Hill’s model with slow growth rate (black squares, panels E–H of Fig 1), or Hill’s model with growth rate estimated from cohort 1 (open black circles, I–L of Fig 1) is shown.
The frequency of reactivation estimated in Pinkevych et al. [2] is shown as dashed lines.
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References

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