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Review
. 2016 Nov;16(11):718-731.
doi: 10.1038/nrc.2016.76. Epub 2016 Aug 26.

The interplay between cell signalling and the mevalonate pathway in cancer

Peter J Mullen  1 , Rosemary Yu  1   2 , Joseph Longo  1   2 , Michael C Archer  2   3 , Linda Z Penn  1   2
Affiliations
Review

The interplay between cell signalling and the mevalonate pathway in cancer

Peter J Mullen et al. Nat Rev Cancer. 2016 Nov.

Abstract

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.

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