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Review
. 2016:2016:1243819.
doi: 10.1155/2016/1243819. Epub 2016 Aug 3.

Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus

Catalina Ionescu  1 , Catalina Gabriela Corbu  2 , Cristiana Tanase  3 , Christian Jonescu-Cuypers  4 , Cristina Nicula  5 , Dana Dascalescu  1 , Miruna Cristea  1 , Liliana-Mary Voinea  6
Affiliations
Review

Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus

Catalina Ionescu et al. Dis Markers. 2016.

Abstract

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.

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Figures

Figure 1
Figure 1
Adapted by Galvis et al. [8], illustrating the interplay between cytokines, proteases, and antioxidants and their complex multidirectional actions.
See this image and copyright information in PMC

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