Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug 3;14(8):975-977.
doi: 10.1080/15476286.2016.1227903. Epub 2016 Aug 26.

Early history of circular RNAs, children of splicing

Zvi Pasman  1 , Mariano A Garcia-Blanco  2   3
Affiliations

Early history of circular RNAs, children of splicing

Zvi Pasman et al. RNA Biol. .

Abstract

In this commentary we briefly summarize early work on circular RNAs derived from spliceosome mediated circularization. We highlight how this early work inspired work on the basic mechanisms of nuclear RNA splicing, the possible function of circular RNAs and the potential uses of circular RNAs as tools in biomedicine. Recent developments in the study of circular RNAs, summarized in this volume, have brought these questions back to the foreground.

Keywords: Circular RNA; Sry; exon circularization; splice site approximation; spliceosome mediated splicing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Aebi M, Hornig H, Padgett RA, Reiser J, Weissmann C. Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell 1986; 47(4):555-65; PMID:3779836; https://doi.org/26938010.1016/0092-8674(86)90620-3 - DOI - PubMed
    1. Berget SM, Moore C, Sharp PA. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc Natl Acad Sci U S A 1977; 74(8):3171-5; PMID:269380; https://doi.org/10.1073/pnas.74.8.3171 - DOI - PMC - PubMed
    1. Beyer AL, Osheim YN. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev 1988; 2(6):754-65; PMID:3138163; https://doi.org/10.1101/gad.2.6.754 - DOI - PubMed
    1. Bohjanen PR, Colvin RA, Puttaraju M, Been MD, Garcia-Blanco MA. A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription. Nucleic Acids Res 1996; 24(19):3733-8; PMID:8871552; https://doi.org/10.1093/nar/24.19.3733 - DOI - PMC - PubMed
    1. Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, Goodfellow P, Lovell-Badge R. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell 1993; 73(5):1019-30; PMID:7684656; https://doi.org/610120310.1016/0092-8674(93)90279-Y - DOI - PubMed

Publication types

LinkOut - more resources