Evaluation of the Global Lung Initiative 2012 Reference Values for Spirometry in African Children

Abstract

Rationale: Despite the high burden of respiratory disease, no spirometry reference values for African children are available.

Objectives: Investigate whether the Global Lung Initiative (GLI-2012) reference values for spirometry are appropriate for children in sub-Saharan Africa and assess the impact of malnutrition on lung function.

Methods: Anthropometry and spirometry were obtained in children aged 6 to 12 years from urban and semiurban schools in three African countries. Spirometry z-scores were derived using the GLI-2012 prediction equations for African Americans. Thinness (body mass index z-score < -2) was a surrogate for malnutrition. Spirometry outcomes were compared with those of African American children from the third National Health and Nutrition Survey.

Measurements and main results: Spirometry data were analyzed from 1,082 schoolchildren (51% boys) aged 6.0 to 12.8 years in Angola (n = 306), Democratic Republic of the Congo (n = 377), and Madagascar (n = 399). GLI-2012 provided a good fit with mean (SD) z-scores of -0.11 (0.83) for FEV₁, -0.08 (0.86) for FVC, and -0.07 (0.83) for FEV₁/FVC. Because of low scatter, the fifth centile corresponded to -1.3 z-scores in boys and -1.5 z-scores in girls. Malnourished African children had a normal FEV₁/FVC ratio but significant reductions of ∼0.5 z-scores (∼5%) in FEV₁ and FVC compared with African American peers from the third National Health and Nutrition Survey. Children in Angola had the lowest, and those in Madagascar had the highest, zFEV₁ and zFVC.

Conclusions: The results of this study support the use of GLI-2012 reference values for schoolchildren in sub-Saharan Africa. Malnutrition affects body growth, leading to a proportionately smaller FEV₁ and FVC without respiratory impairment, as shown by the normal FEV₁/FVC ratio.

Keywords: Africa; malnutrition; pediatrics; reference values; spirometry.