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Review
. 2017 Jan;69(1):9-21.
doi: 10.1002/art.39842.

Review: Metabolic Regulation of Inflammation in Osteoarthritis

Francis Berenbaum  1 , Timothy M Griffin  2 , Ru Liu-Bryan  3
Affiliations
Review

Review: Metabolic Regulation of Inflammation in Osteoarthritis

Francis Berenbaum et al. Arthritis Rheumatol. 2017 Jan.
No abstract available

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Figures

Figure 1
Figure 1. Cardiometabolic factors and associated mediators of increased OA pathophysiology
The clustering of cardiometabolic conditions that collectively increase the risk of heart disease, diabetes, and stroke are referred to as the Metabolic Syndrome (MetS). Emerging data indicate that the MetS also increases OA risk by impairing the regulation of numerous metabolic and inflammatory pathways, including adipose tissue inflammation, blood glucose and lipid homeostasis, and vascular inflammation. Dysregulation of these signaling pathways impact multiple articular joint tissues either directly or indirectly through disrupted tissue paracrine signaling and/or biomechanical function. The net result is an increase in synovial and intra-articular fat inflammation, impaired bone remodeling, and the suppression of cartilage anabolic activity in favor of catabolism.
Figure 2
Figure 2. AMPK and sirtuins as potential therapeutic targets for OA
Aging, joint injury, low-grade inflammation, and possibly altered metabolism resulted from nutritional overload, obesity or MetS impair activities energy sensors AMPK and sirtuins in articular cartilage. In turn, the dysregulated signaling of AMPK and/or sirtuins triggers significant chondrocyte stress by inducing mitochondrial dysfunction, oxidative stress, and inflammation and weakening cellular quality control that compromise cell survival and cartilage tissue integrity, ultimately leading to OA development and progression. However, targeted activation of AMPK and sirtuins potentially by dietary restriction, natural plant products used as dietary supplements (e.g. berberine, resveratrol), and drugs already in the clinic (e.g. metformin for type 2 diabetes, methotrexate for rheumatoid arthritis) could be an attractive therapeutic strategy for OA, particularly for those OA patients who also have MetS. Note: *predicted pathways.
See this image and copyright information in PMC

References

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