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Editorial
. 2016 Oct;10(10):1039-40.
doi: 10.1080/17476348.2016.1227257. Epub 2016 Sep 6.

Can we prevent childhood asthma before birth? Summary of the VDAART results so far

Scott T Weiss  1 , Augusto A Litonjua  1
Affiliations
Editorial

Can we prevent childhood asthma before birth? Summary of the VDAART results so far

Scott T Weiss et al. Expert Rev Respir Med. 2016 Oct.

Abstract

When VDAART was launched we assumed the effects of vitamin D were confined to the alveolar stage of lung development i.e. the third trimester. Fetal lung expression data and a demonstration that vitamin D influenced early fetal lung development emerged after the trial was under way. Finally, initial level of vitamin D at trial entry misclassified subjects at entry to the trial. Initial nutrient level is an important modifier of trial response in VDAART and intent to treat analyses stratified by initial level show a greater effect of vitamin D than iwasseen when initial level is not accounted for.

Keywords: VDAART; Vitamin D; asthma; childhood asthma; clinical trial; epidemiology.

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Conflict of interest statement

Declaration of interest The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

Comment on

References

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