Association of knee pain and different definitions of knee osteoarthritis with health-related quality of life: a population-based cohort study in southern Sweden

doi:10.1186/s12955-016-0525-4

. 2016 Aug 26;14(1):121.

doi: 10.1186/s12955-016-0525-4.

Association of knee pain and different definitions of knee osteoarthritis with health-related quality of life: a population-based cohort study in southern Sweden

Aliasghar A Kiadaliri^{1

2

3}, Carl Johan Lamm⁴, Maria Gerhardsson de Verdier⁵, Gunnar Engström⁶, Aleksandra Turkiewicz⁷, L Stefan Lohmander^{7

8

9}, Martin Englund^{7

10

11}

Affiliations

¹ Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden. aliasghar.ahmad_kiadaliri@med.lu.se.
² Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. aliasghar.ahmad_kiadaliri@med.lu.se.
³ Skånes University Hospital, Clinical Epidemiology Unit, Klinikgatan 22, SE-221 85, Lund, Sweden. aliasghar.ahmad_kiadaliri@med.lu.se.
⁴ Astra Zeneca R&D, Mölndal, Sweden.
⁵ Astra Zeneca R&D, Gothenburg, Sweden.
⁶ Cardiovascular Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
⁷ Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden.
⁸ Research Unit for Musculoskeletal Function and Physiotherapy, University of Southern Denmark, Odense, Denmark.
⁹ Department of Orthopedics and Traumatology, University of Southern Denmark, Odense, Denmark.
¹⁰ Epidemiology and Register Centre South, Skåne University Hospital, Lund, Sweden.
¹¹ Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.

PMID: 27565135
PMCID: PMC5002211
DOI: 10.1186/s12955-016-0525-4

Association of knee pain and different definitions of knee osteoarthritis with health-related quality of life: a population-based cohort study in southern Sweden

Aliasghar A Kiadaliri et al. Health Qual Life Outcomes. 2016.

. 2016 Aug 26;14(1):121.

doi: 10.1186/s12955-016-0525-4.

Authors

Aliasghar A Kiadaliri^{1

2

3}, Carl Johan Lamm⁴, Maria Gerhardsson de Verdier⁵, Gunnar Engström⁶, Aleksandra Turkiewicz⁷, L Stefan Lohmander^{7

8

9}, Martin Englund^{7

10

11}

Affiliations

¹ Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden. aliasghar.ahmad_kiadaliri@med.lu.se.
² Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. aliasghar.ahmad_kiadaliri@med.lu.se.
³ Skånes University Hospital, Clinical Epidemiology Unit, Klinikgatan 22, SE-221 85, Lund, Sweden. aliasghar.ahmad_kiadaliri@med.lu.se.
⁴ Astra Zeneca R&D, Mölndal, Sweden.
⁵ Astra Zeneca R&D, Gothenburg, Sweden.
⁶ Cardiovascular Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
⁷ Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden.
⁸ Research Unit for Musculoskeletal Function and Physiotherapy, University of Southern Denmark, Odense, Denmark.
⁹ Department of Orthopedics and Traumatology, University of Southern Denmark, Odense, Denmark.
¹⁰ Epidemiology and Register Centre South, Skåne University Hospital, Lund, Sweden.
¹¹ Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.

PMID: 27565135
PMCID: PMC5002211
DOI: 10.1186/s12955-016-0525-4

Abstract

Background: While the impact of knee pain and knee osteoarthritis (OA) on health-related quality of life (HRQoL) has been investigated in the literature, there is a lack of knowledge on the impact of different definitions of OA on HRQoL. The main aim of this study was to measure and compare the impact of knee OA and its different definitions on HRQoL in the general population.

Methods: A random sample of 1300 participants from Malmö, Sweden with pain in one or both knees in the past 12 months with duration ≥4 weeks and 650 participants without were invited to clinical and radiographic knee examination. A total of 1527 individuals with a mean (SD) age 69.4 (7.2) participated and responded to both generic (EQ-5D-3L) and disease-specific (the Knee injury and Osteoarthritis Outcome Score) questionnaires. Knee pain was defined as pain during the last month during most of the days. Knee OA was defined radiographically (equivalent to Kellgren and Lawrence grade ≥2) and clinically according to the American College of Rheumatology (ACR) criteria.

Results: Of participants with either knee pain or knee OA or both, 7 % reported no problem for the EQ-5D-3L attributes. The corresponding proportion among references (neither knee pain nor OA) was 42 %. The participants with knee pain and OA had all HRQoL measures lower compared to those with knee pain but no OA. The ACR clinical definition of knee OA was associated with lower HRQoL than the definition based on radiographic knee OA (adjusted difference -0.08 in UK EQ-5D-3L index score).

Conclusions: Applying different definitions of knee OA result in different levels of HRQoL and this is mainly explained by the knee pain experience. These differences may lead to discrepant conclusions from cost-utility analyses.

Keywords: EQ-5D-3L; KOOS; Knee osteoarthritis; Knee pain; Quality of life; Sweden.

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References

1. Felson DT. The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin Arthritis Rheum. 1990;20:42–50. doi: 10.1016/0049-0172(90)90046-I. - DOI - PubMed
1. Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L, et al. Osteoarthritis. Best Pract Res Clin Rheumatol. 2010;24:757–68. doi: 10.1016/j.berh.2010.11.001. - DOI - PubMed
1. Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis. 2007;66:158–62. doi: 10.1136/ard.2006.053538. - DOI - PMC - PubMed
1. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26:355–69. doi: 10.1016/j.cger.2010.03.001. - DOI - PMC - PubMed
1. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–30. doi: 10.1136/annrheumdis-2013-204763. - DOI - PubMed

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[1] Felson DT. The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin Arthritis Rheum. 1990;20:42–50. doi: 10.1016/0049-0172(90)90046-I. - DOI - PubMed

[2] Felson DT. The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin Arthritis Rheum. 1990;20:42–50. doi: 10.1016/0049-0172(90)90046-I. - DOI - PubMed

[3] Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L, et al. Osteoarthritis. Best Pract Res Clin Rheumatol. 2010;24:757–68. doi: 10.1016/j.berh.2010.11.001. - DOI - PubMed

[4] Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L, et al. Osteoarthritis. Best Pract Res Clin Rheumatol. 2010;24:757–68. doi: 10.1016/j.berh.2010.11.001. - DOI - PubMed

[5] Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis. 2007;66:158–62. doi: 10.1136/ard.2006.053538. - DOI - PMC - PubMed

[6] Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis. 2007;66:158–62. doi: 10.1136/ard.2006.053538. - DOI - PMC - PubMed

[7] Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26:355–69. doi: 10.1016/j.cger.2010.03.001. - DOI - PMC - PubMed

[8] Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26:355–69. doi: 10.1016/j.cger.2010.03.001. - DOI - PMC - PubMed

[9] Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–30. doi: 10.1136/annrheumdis-2013-204763. - DOI - PubMed

[10] Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–30. doi: 10.1136/annrheumdis-2013-204763. - DOI - PubMed

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Association of knee pain and different definitions of knee osteoarthritis with health-related quality of life: a population-based cohort study in southern Sweden

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Association of knee pain and different definitions of knee osteoarthritis with health-related quality of life: a population-based cohort study in southern Sweden

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