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. 2016 Aug 25;166(5):1080-1081.
doi: 10.1016/j.cell.2016.08.014.

Tag Team Ubiquitin Ligases

Gary Kleiger  1 , Raymond Deshaies  2
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Free article
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Tag Team Ubiquitin Ligases

Gary Kleiger et al. Cell. .
Free article

Abstract

Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

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