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Comment
. 2016 Nov;65(11):1919-1920.
doi: 10.1136/gutjnl-2016-312722. Epub 2016 Aug 26.

A practical guide to assess the Nancy histological index for UC

Aude Marchal-Bressenot  1 , Alexis Scherl  2 , Julia Salleron  3 , Laurent Peyrin-Biroulet  4   5
Affiliations
Comment

A practical guide to assess the Nancy histological index for UC

Aude Marchal-Bressenot et al. Gut. 2016 Nov.
No abstract available

Keywords: HISTOPATHOLOGY; IBD CLINICAL; ULCERATIVE COLITIS.

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Conflict of interest statement

Competing interests: LP-B, consulting fees from Merck, Abbvie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillots, Vifor, Therakos, Pharmacosmos, Pilège, BMS, UCB-pharma, Hospira, Celltrion, Takeda, Biogaran, Boerhinger-Ingelheim, Lilly, Pfizer, HAC-Pharma, Index Pharmaceuticals, Amgen, Sandoz. Lecture fees from Merck, Abbvie, Takeda, Janssen, Takeda, Ferring, Norgine, Tillots, Vifor, Therakos, Mitsubishi, HAC-pharma. JS and AM-B, none. AS is a Genentech employee.

Figures

Figure 1
Figure 1
(A) Ulceration of colonic mucosa with inflamed granulation tissue corresponding to grade 4 of the Nancy index (HES ×200). (B) Ulceration of colonic mucosa with neutrophils in fibrin corresponding to grade 4 of the Nancy index (HES ×200). (C) Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent. Acute inflammatory cells infiltrate is moderate to severe, corresponding to grade 3 of the Nancy index. (HES ×200). (D) Presence of few or rare neutrophils in lamina propria or in the epithelium that are difficult to see. Acute inflammatory cells infiltrate is mild, corresponding to grade 2 of the Nancy index (HES ×200). (E) Biopsy specimen showing no acute inflammatory cells infiltrate and presence of a moderate-to-severe increase in chronic inflammatory cells number corresponding to grade 1 of the Nancy index (HES ×200). (F) Biopsy specimen showing a mild increase in chronic inflammatory cell number. In this case, it defines a grade 0 of the Nancy index (HES ×200). HES, hematoxylin-eosin-saffron.
See this image and copyright information in PMC

Comment on

  • Development and validation of the Nancy histological index for UC.
    Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold MD, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L. Marchal-Bressenot A, et al. Gut. 2017 Jan;66(1):43-49. doi: 10.1136/gutjnl-2015-310187. Epub 2015 Oct 13. Gut. 2017. PMID: 26464414

References

    1. Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, et al. . Development and validation of the Nancy histological index for UC. Gut Published Online First 13 Oct 2015. doi:10.1136/gutjnl-2015-310187 doi:10.1136/gutjnl-2015-310187 - DOI - PubMed

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