[Pathophysiology of hemorragic shock]

Abstract

This review addresses the pathophysiology of hemorrhagic shock, a condition produced by rapid and significant loss of intravascular volume, which may lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. The initial neuroendocrine response is mainly a sympathetic activation. Haemorrhagic shock is associated altered microcirculatory permeability and visceral injury. It is also responsible for a complex inflammatory response associated with hemostasis alteration.

Keywords: Choc hémorragique; Coagulopathie; Coagulopathy; Hemorrhagic shock; Inflammation; Oxygen delivery; Transport d’oxygène.