Review
doi: 10.1016/j.tcb.2016.07.009.
Epub 2016 Aug 24.
β-Catenin-Independent Roles of Wnt/LRP6 Signaling
Affiliations
- PMID: 27568239
- DOI: 10.1016/j.tcb.2016.07.009
Item in Clipboard
Review
β-Catenin-Independent Roles of Wnt/LRP6 Signaling
Trends Cell Biol.
2016 Dec.
Abstract
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
Keywords: GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Similar articles
-
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.Oncogene. 2015 Sep 17;34(38):4914-27. doi: 10.1038/onc.2014.416. Epub 2014 Dec 15. Oncogene. 2015. PMID: 25500543 Free PMC article.
-
Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling.Biochem Biophys Res Commun. 2013 Jun 28;436(2):338-43. doi: 10.1016/j.bbrc.2013.05.104. Epub 2013 Jun 4. Biochem Biophys Res Commun. 2013. PMID: 23743195
-
LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells.Int J Biochem Cell Biol. 2012 Nov;44(11):1970-82. doi: 10.1016/j.biocel.2012.07.025. Epub 2012 Aug 2. Int J Biochem Cell Biol. 2012. PMID: 22871567
-
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.Nutrients. 2015 Jun 3;7(6):4453-64. doi: 10.3390/nu7064453. Nutrients. 2015. PMID: 26046396 Free PMC article. Review.
-
Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization.Cells. 2019 Sep 25;8(10):1148. doi: 10.3390/cells8101148. Cells. 2019. PMID: 31557964 Free PMC article. Review.
Cited by
-
The self-fulfilling prophecy of pulmonary fibrosis: a selective inspection of pathological signalling loops.Eur Respir J. 2020 Nov 26;56(5):2000075. doi: 10.1183/13993003.00075-2020. Print 2020 Nov. Eur Respir J. 2020. PMID: 32943406 Free PMC article. Review.
-
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.J Clin Invest. 2019 Jul 25;129(10):4393-4407. doi: 10.1172/JCI129107. J Clin Invest. 2019. PMID: 31343991 Free PMC article.
-
miR-29c-5p knockdown reduces inflammation and blood-brain barrier disruption by upregulating LRP6.Open Med (Wars). 2022 Feb 22;17(1):353-364. doi: 10.1515/med-2022-0438. eCollection 2022. Open Med (Wars). 2022. PMID: 35799601 Free PMC article.
-
A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.Front Genet. 2022 Apr 26;13:878036. doi: 10.3389/fgene.2022.878036. eCollection 2022. Front Genet. 2022. PMID: 35559026 Free PMC article.
-
Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond.Front Cell Dev Biol. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34589484 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
