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Review
. 2016 Dec;26(12):956-967.
doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24.

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Sergio P Acebron  1 , Christof Niehrs  2
Affiliations
Review

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Sergio P Acebron et al. Trends Cell Biol. 2016 Dec.

Abstract

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.

Keywords: GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin.

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