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Case Reports
. 2016 Aug 8:4:2050313X16660485.
doi: 10.1177/2050313X16660485. eCollection 2016.

A case of iloperidone overdose in a 27-year-old man with cocaine abuse

Jin Amon  1 , Elsa Stephen  1 , Rif S El-Mallakh  1
Affiliations
Case Reports

A case of iloperidone overdose in a 27-year-old man with cocaine abuse

Jin Amon et al. SAGE Open Med Case Rep. .

Abstract

Introduction: Iloperidone is a recently introduced antipsychotic medication. It is approved for the treatment of schizophrenia. There are no published reports of iloperidone overdosage, but there are eight cases that have been reported to the US Food and Drug Administration.

Case report: A case of a 27-year-old man who took 84 mg of iloperidone while also smoking cocaine is described. He developed a prolonged QTc (527 ms) without arrhythmias and respiratory failure with mandated respiratory support. He ultimately recovered without sequelae.

Discussion: The information regarding previous cases of toxicity on the US Food and Drug Administration website is incomplete. However, there were no fatalities due to iloperidone over-ingestion. Prolongation of the QTc may be a common feature.

Keywords: Iloperidone; QT; QTc; overdosage; toxicity.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: El-Mallakh receives research funding from the National Institute of Mental Health, the State of Kentucky, and the following companies: Merck, PsychNostics, and Teva. He is on the speakers’ bureau of Allergan, Lundbeck, Merck, Otsuka, Sunovion, and Takeda. None of the other authors have any conflicts of interest to declare.

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