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. 2016 Sep;37(9):968-72.
doi: 10.15537/smj.2016.9.15838.

Correlation between mycosis fungoides and pregnancy

Farahnaz Fatemi Naeini  1 , Bahareh Abtahi-Naeini, Jamshid Najafian, Ali Saffaei, Mohsen Pourazizi
Affiliations

Correlation between mycosis fungoides and pregnancy

Farahnaz Fatemi Naeini et al. Saudi Med J. 2016 Sep.

Abstract

Objectives: To evaluate the effect of pregnancy on the natural course of Mycosis fungoides (MF) and compare the obtained results with previous reports.

Methods: The medical records of 140 patients with cutaneous T-cell lymphoma (CTCL) treated at the University Hospital of Isfahan (the academic referral center for CTCL) Isfahan, Iran. Between 2000 and 2013 were retrospectively reviewed to retrieve all cases of pregnancy during the course of MF disease.

Results: A total of 8 pregnancies were recorded. The median age of patients at the time of diagnosis was 26.7 (range 21-30 years) and pregnancy 29.4 (range 27-31 years). Most of patients had early-stage MF (Ia and Ib). All patients experienced aggravation of disease during pregnancy or immediately postpartum. Mycosis fungoides did not cause any complications during pregnancy.

Conclusion: Pregnancy appears to have a negative impact on the course of MF, probably due to immune system deteriorations during the pregnancy. Further studies are needed to clarify the interplay between pregnancy and MF.

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Figures

Figure 1
Figure 1
Histopathological feature of the patch stage of mycosis fungoides. Sections from the patch show epidermotropism of atypical lymphocytes, mostly in basal layer and dermis, mild interstitial infiltrate of small lymphocytes are seen (Hematoxylin and eosin ×100) (arrow).
Figure 2
Figure 2
Mycosis fungoides, an erythematous scaly patch in the upper part of left tight in a 31 years-old female during pregnancy.
See this image and copyright information in PMC

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References

    1. Naeini FF, Abtahi-Naeini B, Pourazizi M, Sadeghiyan H, Najafian J. Primary cutaneous lymphomas: A clinical and histological study of 99 cases in Isfahan, Iran. J Res Med Sci. 2015;20:827–831. - PMC - PubMed
    1. Fatemi Naeini F, Abtahi-Naeini B, Sadeghiyan H, Nilforoushzadeh MA, Najafian J, Pourazizi M. Mycosis fungoides in Iranian population: an epidemiological and clinicopathological study. J Skin Cancer. 2015;2015:306543. - PMC - PubMed
    1. Olek-Hrab K, Silny W. Diagnostics in mycosis fungoides and Sezary syndrome. Rep Pract Oncol Radiother. 2014;19:72–76. - PMC - PubMed
    1. Fernandez-Guarino M. Emerging treatment options for early mycosis fungoides. Clin Cosmet Investig Dermatol. 2013;6:61–69. - PMC - PubMed
    1. Fatemi Naeini F, Sadeghiyan H, Pourazizi M, Najafian J, Abtahi-Naeini B. Characteristics of Primary Cutaneous T-Cell Lymphoma in Iran: A 10-Year Retrospective Study. Int Sch Res Notices. 2014;2014:5. - PMC - PubMed