Atopic dermatitis is associated with reduced corneodesmosin expression: role of cytokine modulation and effects on viral penetration

U H Lee^{1

2}, B E Kim¹, D J Kim², Y G Cho³, Y M Ye⁴, D Y M Leung^{1

5}

Affiliations

¹ Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, U.S.A.
² Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
³ Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea.
⁴ Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
⁵ Hospital of Guangzhou Medical University, Guangzhou, China.

Comment

U H Lee et al. Br J Dermatol. 2017 Feb.

. 2017 Feb;176(2):537-540.

doi: 10.1111/bjd.15010. Epub 2016 Oct 2.

U H Lee^{1

2}, B E Kim¹, D J Kim², Y G Cho³, Y M Ye⁴, D Y M Leung^{1

5}

¹ Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, U.S.A.
² Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
³ Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea.
⁴ Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
⁵ Hospital of Guangzhou Medical University, Guangzhou, China.

No abstract available

Comment on

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.
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The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis.
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