Neuromyelitis optica spectrum disorders in children and adolescents

Silvia Tenembaum¹, Tanuja Chitnis², Ichiro Nakashima², Nicolas Collongues², Andrew McKeon², Michael Levy², Kevin Rostasy²

Affiliations

¹ From the Department of Pediatric Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (I.N.), Tohoku University School of Medicine, Sendai, Japan; Department of Neurology (N.C.), University Hospitals Strasbourg, Center for Clinical Investigation, INSERM, Strasbourg, France; Departments of Laboratory Medicine and Pathology and Neurology (A.M.), Mayo Clinic, Rochester, MN; Department of Neurology (M.L.), Neuromyelitis Optica Clinic, Johns Hopkins University, Baltimore, MD; and Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany. silviatenembaum@gmail.com.
² From the Department of Pediatric Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (I.N.), Tohoku University School of Medicine, Sendai, Japan; Department of Neurology (N.C.), University Hospitals Strasbourg, Center for Clinical Investigation, INSERM, Strasbourg, France; Departments of Laboratory Medicine and Pathology and Neurology (A.M.), Mayo Clinic, Rochester, MN; Department of Neurology (M.L.), Neuromyelitis Optica Clinic, Johns Hopkins University, Baltimore, MD; and Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany.

PMID: 27572863
DOI: 10.1212/WNL.0000000000002824

Review

Neuromyelitis optica spectrum disorders in children and adolescents

Silvia Tenembaum et al. Neurology. 2016.

. 2016 Aug 30;87(9 Suppl 2):S59-66.

doi: 10.1212/WNL.0000000000002824.

Authors

Silvia Tenembaum¹, Tanuja Chitnis², Ichiro Nakashima², Nicolas Collongues², Andrew McKeon², Michael Levy², Kevin Rostasy²

Affiliations

¹ From the Department of Pediatric Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (I.N.), Tohoku University School of Medicine, Sendai, Japan; Department of Neurology (N.C.), University Hospitals Strasbourg, Center for Clinical Investigation, INSERM, Strasbourg, France; Departments of Laboratory Medicine and Pathology and Neurology (A.M.), Mayo Clinic, Rochester, MN; Department of Neurology (M.L.), Neuromyelitis Optica Clinic, Johns Hopkins University, Baltimore, MD; and Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany. silviatenembaum@gmail.com.
² From the Department of Pediatric Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (I.N.), Tohoku University School of Medicine, Sendai, Japan; Department of Neurology (N.C.), University Hospitals Strasbourg, Center for Clinical Investigation, INSERM, Strasbourg, France; Departments of Laboratory Medicine and Pathology and Neurology (A.M.), Mayo Clinic, Rochester, MN; Department of Neurology (M.L.), Neuromyelitis Optica Clinic, Johns Hopkins University, Baltimore, MD; and Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany.

PMID: 27572863
DOI: 10.1212/WNL.0000000000002824

Abstract

Neuromyelitis optica (NMO) is a severe autoimmune disease of the CNS characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. NMO is infrequent in children, but early recognition is important to start adequate treatment. In this article, we review the evolving diagnostic criteria of NMO and provide an update on the clinical and neuroimaging spectrum of the disorder in pediatric patients, including current knowledge on immunopathogenesis and treatment recommendations for children with NMO.

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Neuromyelitis optica spectrum disorders in children and adolescents

Affiliations

Neuromyelitis optica spectrum disorders in children and adolescents

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Affiliations

Abstract

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