Genomics Study of Gastric Cancer and Its Molecular Subtypes

Abstract

Gastric cancer is a heterogeneous disease encompassing diverse morphological (intestinal versus diffuse) and molecular subtypes (MSI, EBV, TP53 mutation). Recent advances in genomic technology have led to an improved understanding of the driver gene mutational profile, gene expression, and epigenetic alterations that underlie each of the subgroups, with therapeutic implications in some of these alterations. There have been attempts to classify gastric cancers based on these genomic features, with an aim to improve prognostication and predict responsiveness to specific drug therapy. The eventual aims of these genomic studies are to develop deep biological insights into the carcinogenic pathway in each of these subtypes. Future large-scale drug screening strategies may then be able to link these genomic features to drug responsiveness, eventually leading to genome-guided personalized medicine with improved cure rates.

Keywords: DNA copy number profiling; Epstein-Barr virus; Gastric adenocarcinoma; Gene expression profiling; Integrative genomics analysis; Methylation profiling; Microsatellite instability; Next-generation sequencing; Whole-exome sequencing; Whole-genome sequencing; miRNA profiling.