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. 2016 Aug 16:10:1531-4.
doi: 10.2147/OPTH.S111526. eCollection 2016.

Long-term surgical outcomes of retinal detachment in patients with Stickler syndrome

Devasis N Reddy  1 , Yoshihiro Yonekawa  2 , Benjamin J Thomas  3 , Eric D Nudleman  4 , George A Williams  5
Affiliations

Long-term surgical outcomes of retinal detachment in patients with Stickler syndrome

Devasis N Reddy et al. Clin Ophthalmol. .

Abstract

Purpose: The aim of the study was to present the long-term anatomical and visual outcomes of retinal detachment repair in patients with Stickler syndrome.

Patients and methods: This study is a retrospective, interventional, consecutive case series of patients with Stickler syndrome undergoing retinal reattachment surgery from 2009 to 2014 at the Associated Retinal Consultants, William Beaumont Hospital.

Results: Sixteen eyes from 13 patients were identified. Patients underwent a mean of 3.1 surgical interventions (range: 1-13) with a mean postoperative follow-up of 94 months (range: 5-313 months). Twelve eyes (75%) developed proliferative vitreoretinopathy. Retinal reattachment was achieved in 100% of eyes, with ten eyes (63%) requiring silicone oil tamponade at final follow-up. Mean preoperative visual acuity (VA) was 20/914, which improved to 20/796 at final follow-up (P=0.81). There was a significant correlation between presenting and final VA (P<0.001), and patients with poorer presenting VA were more likely to require silicone oil tamponade at final follow-up (P=0.04).

Conclusion: Repair of retinal detachment in patients with Stickler syndrome often requires multiple surgeries, and visual outcomes are variable. Presenting VA is significantly predictive of long-term VA outcomes.

Keywords: pediatric retina; proliferative vitreoretinopathy; retina; scleral buckle; vitrectomy; vitreoretinal surgery.

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References

    1. Snead MP, Yates JR. Clinical and molecular genetics of Stickler syndrome. J Med Genet. 1999;36(5):353–359. - PMC - PubMed
    1. Stickler GB, Hughes W, Houchin P. Clinical features of hereditary progressive arthro-ophthalmopathy (Stickler syndrome): a survey. Genet Med. 2001;3(3):192–196. - PubMed
    1. Stickler Syndrome [webpage on the Internet] Genetics Home Reference [updated 2013] [Accessed February 23, 2013]. Available from: http://ghr.nlm.nih.gov/condition/stickler-syndrome.
    1. Snead MP, Mcninch AM, Poulson AV, et al. Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist. Eye (Lond) 2011;25(11):1389–1400. - PMC - PubMed
    1. Robin NH, Moran RT, Ala-Kokko L, webpage on the Internet . Stickler Syndrome; 2000 [updated November 26, 2014] In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews [Internet] Seattle, WA: University of Washington; 1993–2015. [Accessed July 16, 2016]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1302/

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