doi: 10.1016/0003-4975(89)90020-9.
Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics
Affiliations
- PMID: 2757440
- DOI: 10.1016/0003-4975(89)90020-9
Item in Clipboard
Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics
Ann Thorac Surg.
1989 Jun.
Abstract
Antibiotic prophylaxis is used widely to prevent postoperative infection associated with cardiac operations. The influence of perioperative blood loss on antibiotic pharmacokinetics has not been well studied. Plasma cefazolin sodium samples from 8 patients undergoing a cardiac operation were collected postoperatively and analyzed. The results suggest that blood loss has a minimal effect on the elimination of cefazolin and that therapeutic concentrations are maintained without altering the dosage regimen.
Similar articles
-
Comparative study of cefazolin, cefamandole, and vancomycin for surgical prophylaxis in cardiac and vascular operations. A double-blind randomized trial.J Thorac Cardiovasc Surg. 1992 Nov;104(5):1423-34. J Thorac Cardiovasc Surg. 1992. PMID: 1434726 Clinical Trial.
-
Cefazolin and netilmicin serum levels during and after cardiac surgery with cardiopulmonary bypass.J Cardiothorac Anesth. 1990 Apr;4(2):204-9. doi: 10.1016/0888-6296(90)90239-c. J Cardiothorac Anesth. 1990. PMID: 2131868
-
Serum cefazolin levels during spinal fusion: effect of blood loss and duration of surgery.J Spinal Disord. 1993 Aug;6(4):296-9. doi: 10.1097/00002517-199306040-00003. J Spinal Disord. 1993. PMID: 8219543
-
Transfusion medicine : support of patients undergoing cardiac surgery.Am J Cardiovasc Drugs. 2001;1(5):337-51. doi: 10.2165/00129784-200101050-00004. Am J Cardiovasc Drugs. 2001. PMID: 14728016 Review.
-
The conservation of blood during cardiac surgery.Clin Cardiol. 1979 Apr;2(2):155-7. doi: 10.1002/clc.4960020213. Clin Cardiol. 1979. PMID: 400516 Review. No abstract available.
Cited by
-
Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats.Front Pharmacol. 2018 Apr 6;9:328. doi: 10.3389/fphar.2018.00328. eCollection 2018. Front Pharmacol. 2018. PMID: 29681855 Free PMC article.
-
A prospective randomized study to assess the optimal duration of intravenous antimicrobial prophylaxis in elective gastric cancer surgery.Int Surg. 2012 Apr-Jun;97(2):169-76. doi: 10.9738/CC91.1. Int Surg. 2012. PMID: 23102084 Free PMC article. Clinical Trial.
-
Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.J Cardiothorac Surg. 2018 Jun 8;13(1):64. doi: 10.1186/s13019-018-0747-0. J Cardiothorac Surg. 2018. PMID: 29884189 Free PMC article.
-
Physiological modeling for indirect evaluation of drug tissular pharmacokinetics under non-steady-state conditions: an example of antimicrobial prophylaxis during liver surgery.J Pharmacokinet Pharmacodyn. 2005 Feb;32(1):1-32. doi: 10.1007/s10928-005-2101-0. J Pharmacokinet Pharmacodyn. 2005. PMID: 16175313
-
Microbiological efficacy and pharmacokinetics of prophylactic antibiotics in liver transplant patients.Antimicrob Agents Chemother. 1992 Oct;36(10):2125-30. doi: 10.1128/AAC.36.10.2125. Antimicrob Agents Chemother. 1992. PMID: 1444292 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
