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Editorial
. 2016 Dec;68(12):2834-2836.
doi: 10.1002/art.39835.

Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?

Deborah Veis Novack  1
Affiliations
Editorial

Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?

Deborah Veis Novack. Arthritis Rheumatol. 2016 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

conflicts: none

Figures

Figure 1
Figure 1
Cells in the inflammatory pannus found around RA joints, including synovial fibroblasts (SF), Th17 T cells, macrophages (Mac), and osteoblasts (Ob) contribute to an environment high in cytokines such as RANKL, TNFα, and IL-6. TNFα and IL-6 can work together, completely independent of RANKL, to induce differentiation of osteoclasts that secrete cathepsin K (catK) and resorb bone near the joint.
See this image and copyright information in PMC

Comment on

References

    1. Novack DV, Mbalaviele G. Osteoclasts-Key Players in Skeletal Health and Disease. Microbiol Spectr. 2016;4(3) - PMC - PubMed
    1. Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999;402(6759):304–309. - PubMed
    1. Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2004;19(2):207–213. - PubMed
    1. Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. The American journal of pathology. 2001;159(5):1689–1699. - PMC - PubMed
    1. Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(4):1566–1571. - PMC - PubMed