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Case Reports
. 2018 Aug;6(3):228-230.
doi: 10.1093/gastro/gow025. Epub 2016 Aug 29.

Cetirizine-induced hepatotoxicity: case series and review of the literature

Adil Coskun  1 , Irfan Yavasoglu  2 , M Hadi Yasa  3 , Nil Culhaci  4 , Vahit Yukselen  3
Affiliations
Case Reports

Cetirizine-induced hepatotoxicity: case series and review of the literature

Adil Coskun et al. Gastroenterol Rep (Oxf). 2018 Aug.

Abstract

Drug-induced liver damage is a frequently encountered clinical table caused by many drugs. Cetirizine is a widely preferred and prescribed antihistaminic agent for allergic disorders due to its non-sedative properties. In view of the literature, we present four cases of hepatotoxicity due to cetirizine use. We conclude that in patients with high levels of liver enzymes of unknown origin, cetirizine as well as other hepatotoxic drugs should be reconsidered.

Keywords: cetirizine; hepatotoxicity.

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Figures

Figure 1.
Figure 1.
Liver biopsy of Case 3 shows macrosteatosis places (A, hematoxylin-eosin staining, x100) and mixed inflammatory infiltration including eosinophils; (B, hematoxylin-eosin, x200) in portal areas and parenchyma.
See this image and copyright information in PMC

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