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. 2016 Aug 31;14(1):233.
doi: 10.1186/s12957-016-0991-5.

Positive detection of exfoliated colon cancer cells on linear stapler cartridges was associated with depth of tumor invasion and preoperative bowel preparation in colon cancer

Kishiko Ikehara  1 , Shungo Endo  2   3 , Kensuke Kumamoto  4 , Eiji Hidaka  1 , Fumio Ishida  1 , Jun-Ichi Tanaka  1   5 , Shin-Ei Kudo  1
Affiliations

Positive detection of exfoliated colon cancer cells on linear stapler cartridges was associated with depth of tumor invasion and preoperative bowel preparation in colon cancer

Kishiko Ikehara et al. World J Surg Oncol. .

Abstract

Background: The aim of this study was to investigate exfoliated cancer cells (ECCs) on linear stapler cartridges used for anastomotic sites in colon cancer.

Methods: We prospectively analyzed ECCs on linear stapler cartridges used for anastomosis in 100 colon cancer patients who underwent colectomy. Having completed the functional end-to-end anastomosis, the linear stapler cartridges were irrigated with saline, which was collected for cytological examination and cytological diagnoses were made by board-certified pathologists based on Papanicolaou staining.

Results: The detection rate of ECCs on the linear stapler cartridges was 20 %. Positive detection of ECCs was significantly associated with depth of tumor invasion (p = 0.012) and preoperative bowel preparation (p = 0.003). There were no marked differences between ECC-positive and ECC-negative groups in terms of the operation methods, tumor location, histopathological classification, and surgical margins.

Conclusions: Since ECCs were identified on the cartridge of the linear stapler used for anastomosis, preoperative mechanical bowel preparation using polyethylene glycol solution and cleansing at anastomotic sites using tumoricidal agents before anastomosis may be necessary to decrease ECCs in advanced colon cancer.

Keywords: Colon cancer; Exfoliated cancer cell; Functional end-to-end anastomosis; Suture-line recurrence.

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References

    1. Gologher JC, Dukes CE, Bussey HJR. Local recurrences after sphincter saving excisions for carcinoma of the rectum and rectosigmoid. Br J Surg. 1951;39:199–211. doi: 10.1002/bjs.18003915504. - DOI - PubMed
    1. Hardy KJ, Cuthbertson AM, Hughes ES. Suture-line neoplastic recurrence following large-bowel resection. Aust NZ J Surg. 1971;41:44–6. - PubMed
    1. Kyzer S, Gordon PH. The stapled functional end-to-end anastomosis following colonic resection. Int J Colorectal Dis. 1992;7:125–31. doi: 10.1007/BF00360351. - DOI - PubMed
    1. Steichen FM. The use of staplers in anatomical side-to-side and functional end-to-end enteroanastomoses. Surgery. 1968;64:948–53. - PubMed
    1. Docherty JG, McGregor JR, Akyol AM, Murray GD, Galloway DJ. Comparison of manually constructed and stapled anastomoses in colorectal surgery. West of Scotland and Highland anastomosis Study Group. Ann Surg. 1995;221:176–84. doi: 10.1097/00000658-199502000-00008. - DOI - PMC - PubMed

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