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Review
. 2016 Sep 1;143(17):3037-44.
doi: 10.1242/dev.132829.

Slit-Robo signaling

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Review

Slit-Robo signaling

Heike Blockus et al. Development. .

Abstract

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.

Keywords: Angiogenesis; Axon guidance; Development; Migration; Robo; Slit.

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