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Comment
. 2016 Oct 13;128(15):1989-1991.
doi: 10.1182/blood-2016-07-730325. Epub 2016 Aug 30.

An upper bound for the half-removal time of neutrophils from circulation

Morgan Craig  1 , Antony R Humphries  2 , Michael C Mackey  3
Affiliations
Comment

An upper bound for the half-removal time of neutrophils from circulation

Morgan Craig et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
Model schematic and data sources visualized. (A) Neutrophils exit the marrow reservoir at rate R(t) before disappearing from the blood at rate γ. (B) Splined data of neutrophil responses to exogenous G-CSF IV infusions from Krzyzanski et al (Figure 2) and Wang et al (Figure 7). (C) Rate of change in neutrophil numbers in the blood calculated from digitized splined data (from Krzyzanski et al [Figure 2] and Wang et al [Figure 7]), differentiated with respect to time. Note that by 1 day after administration, dN(t)/dt < 0 for each of the 3 sources. (D) Right side of the Inequality 2; the maximal value provides a lower bound for γ.
See this image and copyright information in PMC

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References

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