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. 2016 Jun;48(2):P15-20.

Custodiol Cardioplegia: A Single-Dose Hyperpolarizing Solution

Claus J Preusse  1
Affiliations

Custodiol Cardioplegia: A Single-Dose Hyperpolarizing Solution

Claus J Preusse. J Extra Corpor Technol. 2016 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Temperature dependent changes of the membrane potential of the HTK protected myocardium.
Figure 2.
Figure 2.
Drafted influence of electrolytes on the membrane action potential of the myocardial muscle fiber (left) and influence of different arresting solutions on myocardial oxygen consumption at normothermia. (Bret: unbuffered Bretschneider solution).
Figure 3.
Figure 3.
Relation between Na and Ca concentration in a low-Na cardioplegic solution.
Figure 4.
Figure 4.
Significance of high or low Na concentrations on the osmotic space for effective buffering.
Figure 5.
Figure 5.
Suitable buffer substances for cardioplegia and their pK values.
Figure 6.
Figure 6.
Left ventricular morphology after 5-hr-cardiac-arrest and 20-min-reperfusion postischemically. Hearts of mongrel dogs were initially perfused with either HTK solution or an equivalent solution in which the histidine buffer was replaced by the carnosine buffer.
Figure 7.
Figure 7.
Composition of HTK solution (CUSTODIOL®, Dr. Franz Koehler Chemie, D-64625 Bensheim).
Figure 8.
Figure 8.
Significance of different clinical modes of administration of HTK solution on myocardial energy turnover. All patients suffered from aortic valve disease.
Figure 9.
Figure 9.
Correlation between myocardial oxygen consumption and myocardial creatine phosphate content.
Figure 10.
Figure 10.
Myocardial ATP contents of mongrel dogs being postischemically reperfused for 20 min with a modified Krebs-Henseleit solution. Hearts were protected by different solutions and kept ischemic for different periods at various temperatures (every point represents one experiment).
Figure 11.
Figure 11.
Pathophysiological reasons for an intra- and postoperative development of a low-output syndrome.
See this image and copyright information in PMC

References

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    1. Kong Jh, Kim D. H., Chang B. H.. Comparison of cardioprotection between histidine-tryptophan-ketoglutarate cardioplegia and DelNido cardioplegia in isolated rat hearts. Korean J Thorac Cardiovasc Surg. 2003;36:799–811.
    1. Liu J., Feng Z., Li B., Long C.. The myocardial protection of HTK cardioplegic solution on the long-term ischemic period in pediatric heart surgery. ASAIO J. 2008;54:470–3. - PubMed

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