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. 2016 Jul-Aug;33(4):372-80.
doi: 10.4103/0970-2113.184868.

Impact of socioeconomic status and living condition on latent tuberculosis diagnosis among the tribal population of Melghat: A cohort study

Rajpal S Kashyap  1 , Amit R Nayak  1 , Aliabbas A Husain  1 , Seema D Shekhawat  1 , Ashish R Satav  2 , Ruchika K Jain  1 , Dhananjay V Raje  3 , Hatim F Daginawala  1 , Girdhar M Taori  1
Affiliations

Impact of socioeconomic status and living condition on latent tuberculosis diagnosis among the tribal population of Melghat: A cohort study

Rajpal S Kashyap et al. Lung India. 2016 Jul-Aug.

Abstract

Aims: To study socioeconomic status (SES) and living conditions (LC) as risk factors for latent tuberculosis infection (LTBI) and their impact on QuantiFERON-TB gold (QFT-G) and tuberculin skin test (TST) outcome for determining a better diagnostic test for LTBI in the malnourished tribal population of Melghat.

Settings and design: Six hundred sixty nine participants matching the inclusion criteria were recruited from 10 tribal villages of Melghat region, India.

Subjects and methods: Complete information related to various risk factors and test outcome was obtained on 398 participants, which was analyzed as per predefined conceptual framework. Factors were classified based on their relevance either at individual or household level, and subsequently based on the possibility of intervention. Data were partitioned into concordant and discordant sets depending on test agreement.

Results: In concordant set, the two tests revealed that LTBI was significantly associated with smoking (adjusted odds ratio [aOR]: 2.64 [95% confidence interval [CI]: 1.03-6.79]), tobacco usage (aOR: 2.74 [95% CI: 1.50-4.99]), and malnourishment (aOR: 1.97 [95% CI: 1.12-3.48]) after basic adjustment. Inclusion of latent variable SES and LC in the model has mediating effect on the association of above factors with LTBI. Further, the association of SES and LC with LTBI in concordant set was unaltered in presence of other cofactors. From discordant set, results of QFT-G corroborated with that of concordant set.

Conclusions: Poor SES and LC can be considered as strong risk factors linked with LTBI as compared to malnourishment, which is often targeted in such communities. Further, our study showed QFT-G test as a reliable tool in screening of LTBI in the tribal population of Melghat, India.

Keywords: QuantiFERON-TB gold; tribal; tuberculin skin test; tuberculosis.

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Figures

Figure 1
Figure 1
Study flow diagram
Figure 2
Figure 2
Conceptual framework of the study. Various risk factors for latent tuberculosis were classified according to their effect level (household or individual) and type (modifiable or nonmodifiable)
See this image and copyright information in PMC

References

    1. World Health Organization. Global Tuberculosis Report: WHO Report. Geneva: World Health Organization; 2012. [Last accessed on 2013 Jan 01]. Available from: http://www.who.int/tb/publications/global_report/en/
    1. TB INDIA. Revised National TB Control Programme/Annual Status Report. Government of India. 2012. [Last accessed on 2013 Jan 16]. Available from: http://www.tbcindia.nic.in/pdfs/TB .
    1. Herrera V, Perry S, Parsonnet J, Banaei N. Clinical application and limitations of interferon-gamma release assays for the diagnosis of latent tuberculosis infection. Clin Infect Dis. 2011;52:1031–7. - PubMed
    1. Lienhardt C, Fielding K, Hane AA, Niang A, Ndao CT, Karam F, et al. Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. PLoS One. 2010;5:e10508. - PMC - PubMed
    1. Fietta A, Meloni F, Cascina A, Morosini M, Marena C, Troupioti P, et al. Comparison of a whole-blood interferon-gamma assay and tuberculin skin testing in patients with active tuberculosis and individuals at high or low risk of Mycobacterium tuberculosis infection. Am J Infect Control. 2003;31:347–53. - PubMed