Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Dec 1;1(1):78-80.
doi: 10.1089/cren.2015.0021. eCollection 2015.

Two Unexpected Tumors in a Laparoscopic Nephrectomy Specimen, Including a Rare Tubulocystic Renal-Cell Carcinoma: A Case Report

Jacob Jipp  1 , Daniel Sadowski  2 , Chad Defrain  3 , Bradley Schwartz  2
Affiliations
Case Reports

Two Unexpected Tumors in a Laparoscopic Nephrectomy Specimen, Including a Rare Tubulocystic Renal-Cell Carcinoma: A Case Report

Jacob Jipp et al. J Endourol Case Rep. .

Abstract

We present a case of a 52-year-old Caucasian male who underwent a laparoscopic nephrectomy for an atrophic kidney and was found to have two unexpected, synchronous kidney cancers. He had a remote history of testicular cancer complicated by lymphadenopathy and external ureteral compression. Over time, he developed an atrophic left kidney from obstructive uropathy. Years later, due to flank pain and renal scintigraphy showing minimal function, a laparoscopic nephrectomy was performed. Final pathology demonstrated papillary renal-cell carcinoma (RCC) and tubulocystic RCC. Tubulocystic RCC is a rare neoplasm thought to be an indolent subset of collecting duct carcinoma, but was identified as a unique entity in 2004. Currently, there are ∼100 cases of this neoplasm in the literature.

PubMed Disclaimer

Figures

<b>FIG. 1.</b>
FIG. 1.
Axial (A) and coronal (B) CT slices demonstrating an atrophic left kidney without any identifiable mass or lesion.
<b>FIG. 2.</b>
FIG. 2.
Low-power microscopy demonstrates cystically dilated tubules within a fibrotic stroma. Thyroidization and lymphoid follicles are noted in the surrounding atrophic renal parenchyma.
<b>FIG. 3.</b>
FIG. 3.
There is a hobnail appearance to the lining of the tubules characteristic of tubulocystic renal-cell carcinoma. There are prominent nucleoli and abundant cytoplasm in these neoplastic cells.
See this image and copyright information in PMC

References

    1. Amin MB, Maclennan GT, Gupta R, et al. . Tubulocystic carcinoma of the kidney: Clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol 2009;33:384–392 - PubMed
    1. Bhullar JS, Varshney N, Bhullar AK, Mittal VK. A new type of renal cancer-tubulocystic carcinoma of the kidney: A review of the literature. Int J Surg Pathol 2014;22:297–302 - PubMed
    1. Yang XJ, Zhou M, Hes O, et al. . Tubulocystic carcinoma of the kidney: Clinicopathologic and molecular characterization. Am J Surg Pathol 2008;32:177–187 - PubMed
    1. Mego M, Sycova-mila Z, Rejlekova K, et al. . Sunitinib in the treatment of tubulocystic carcinoma of the kidney. A case report. Ann Oncol 2008;19:1655–1656 - PubMed
    1. Maclennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: Report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 1997;50:679–684 - PubMed

Publication types

LinkOut - more resources