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. 2017 Mar 4;8(2):133-136.
doi: 10.1080/21655979.2016.1218579. Epub 2016 Aug 31.

Chaperones in maturation of molybdoenzymes: Why specific is better than general?

Olivier N Lemaire  1 , Sophie Bouillet  1 , Vincent Méjean  1 , Chantal Iobbi-Nivol  1 , Olivier Genest  1
Affiliations

Chaperones in maturation of molybdoenzymes: Why specific is better than general?

Olivier N Lemaire et al. Bioengineered. .

Abstract

Molybdoenzymes play essential functions in living organisms and, as a result, in various geochemical cycles. It is thus crucial to understand how these complex proteins become highly efficient enzymes able to perform a wide range of catalytic activities. It has been established that specific chaperones are involved during their maturation process. Here, we raise the question of the involvement of general chaperones acting in concert with dedicated chaperones or not.

Keywords: general chaperone; maturation; molybdenum cofactor; molybdoenzymes; pyranopterin monophosphate; specific chaperone.

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Figures

Figure 1.
Figure 1.
Maturation of molybdoenzymes: A product of team work? MoMPT: molybdenum cofactor; MobA: bacterial enzyme involved in the final step of molybdenum cofactor biogenesis.
See this image and copyright information in PMC

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