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Observational Study
. 2016 Aug 31;16(1):153.
doi: 10.1186/s12886-016-0313-2.

Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy

Libin Jiang  1 , Lanlan Chen  2 , Xiujuan Qiu  3 , Ran Jiang  3   4 , Yaxing Wang  3   4 , Liang Xu  3   4 , Timothy Y Y Lai  5
Affiliations
Observational Study

Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy

Libin Jiang et al. BMC Ophthalmol. .

Abstract

Background: Non-arteritic anterior ischemic optic neuropathy (NA-AION) is one of the most common types of ischemic optic neuropathy. Several recent studies suggested that abnormalities of choroidal thickness might be associated with NA-AION. The main objective of this case-control study was to evaluate whether choroidal thickness is an ocular risk factor for the development of NA-AION by evaluating the peripapillary and subfoveal choroidal thicknesses in affected Chinese patients.

Methods: Forty-four Chinese patients with unilateral NA-AION were recruited and compared with 60 eyes of 60 normal age and refractive-error matched control subjects. Peripapillary and subfoveal choroidal thicknesses were measured by enhanced depth imaging optical coherence tomography. Choroidal thicknesses of eyes with NA-AION and unaffected fellow eyes were compared with normal controls. Choroidal thicknesses of NA-AION eyes with or without optic disc edema were also compared. The correlation between choroidal thickness and retinal nerve fiber layer (RNFL) thickness, logMAR best-corrected visual acuity (BCVA), and the mean deviation (MD) of Humphrey static perimetry in NA-AION eyes were analyzed.

Results: The peripapillary choroidal thicknesses at the nasal, nasal inferior and temporal inferior segments in NA-AION eyes with optic disc edema were significantly thicker compared with that of normal subjects (P < 0.05). There was no significant difference in the choroidal thicknesses between the unaffected fellow eyes of NA-AION patients and normal eyes of healthy controls; or between the NA-AION eyes with resolved optic disc edema and normal eyes (all P > 0.05). No significant correlation between choroidal thickness and RNFL thickness, logMAR BCVA and perimetry MD was found in eyes affected by NA-AION (all P > 0.05).

Conclusions: Increase in peripapillary choroid thickness in some segments was found in NA-ION eyes with optic disc edema. However, our findings do not support the hypothesis that choroidal thickness is abnormal in Chinese patients with NA-AION compared with normal subjects with similar age and refractive error status.

Keywords: Choroidal thickness; Non-arteritic anterior ischemic optic neuropathy; Optical coherence tomography.

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Figures

Fig 1
Fig 1
Enhanced depth optical coherence tomography scan with 360° 3.4 mm diameter peripapillary circle scan for measurement of choroidal thickness. a Diagram showing segmentation of the peripapillary choroidal thickness measurements in the arithmetic mean of sum in each segment (G) and six segments including nasal superior (NS), nasal (N), nasal inferior (NI), temporal inferior (TI), temporal (T), temporal superior (TS) segments. b Manual delineation of the choroidal layer between the outer border of the retinal pigment epithelium and the inner surface of the sclera for measurement of choroidal thickness
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