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Review
. 2016 Sep;29(3):239-45.
doi: 10.1055/s-0036-1584500.

Low Anterior Resection Syndrome: Current Management and Future Directions

Timothy J Ridolfi  1 , Nicholas Berger  1 , Kirk A Ludwig  1
Affiliations
Review

Low Anterior Resection Syndrome: Current Management and Future Directions

Timothy J Ridolfi et al. Clin Colon Rectal Surg. 2016 Sep.

Abstract

Outcomes for rectal cancer surgery have improved significantly over the past 20 years with increasing rates of survival and recurrence, specifically local recurrence. These gains have been realized during a period of time in which there has been an increasing emphasis on sphincter preservation. As we have become increasingly aggressive in avoiding resection of the anus, we have begun accepting bowel dysfunction as a normal outcome. Low anterior resection syndrome, defined as a constellation of symptoms including incontinence, frequency, urgency, or feelings of incomplete emptying, has a significant impact on quality of life and results in many patients opting for a permanent colostomy to avoid these symptoms. In this article, we will highlight the most recent clinical and basic science research on this topic and discuss areas of future investigation.

Keywords: LAR syndrome; low anterior resection; rectal cancer.

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References

    1. Monson J R, Weiser M R, Buie W D. et al.Practice parameters for the management of rectal cancer (revised) Dis Colon Rectum. 2013;56(5):535–550. - PubMed
    1. Dennett E R, Parry B R. Misconceptions about the colonic J-pouch: what the accumulating data show. Dis Colon Rectum. 1999;42(6):804–811. - PubMed
    1. Juul T, Ahlberg M, Biondo S. et al.Low anterior resection syndrome and quality of life: an international multicenter study. Dis Colon Rectum. 2014;57(5):585–591. - PubMed
    1. Bryant C L, Lunniss P J, Knowles C H, Thaha M A, Chan C L. Anterior resection syndrome. Lancet Oncol. 2012;13(9):e403–e408. - PubMed
    1. Ishiyama G, Hinata N, Kinugasa Y, Murakami G, Fujimiya M. Nerves supplying the internal anal sphincter: an immunohistochemical study using donated elderly cadavers. Surg Radiol Anat. 2014;36(10):1033–1042. - PubMed