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. 2016 Sep 16;18(18):4594-7.
doi: 10.1021/acs.orglett.6b02243. Epub 2016 Sep 1.

Palladium-Catalyzed Regioselective C8-H Amination of 1-Naphthylamine Derivatives with Aliphatic Amines

Zexian Li  1 , Suyan Sun  1 , Huijie Qiao  1 , Fan Yang  1 , Yu Zhu  1 , Jianxun Kang  1 , Yusheng Wu  2   3 , Yangjie Wu  1
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Palladium-Catalyzed Regioselective C8-H Amination of 1-Naphthylamine Derivatives with Aliphatic Amines

Zexian Li et al. Org Lett. .

Abstract

A simple and facile protocol for palladium-catalyzed picolinamide-directed C8-H amination of 1-naphthylamine derivatives with simple secondary aliphatic amines was developed, thereby providing a new route to 1,8-naphthalenediamine derivatives. It is noteworthy that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation.

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